caa a22 4500 445340541 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2407-3 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2407-3 Comparative Efficacy of Trichlorphon and Trichlorphon/Ivermectin Combination Treatment against Anthelmintic-Resistant Cattle Nematodes in Argentina [Elektronische Daten] [César Fiel, Maricel Guzmán, Pedro Steffan, Olegario Prieto, Chandra Bhushan] Twenty-four Holando Argentino male calves were treated orally with 50mg/kg body weight trichlorphon (TCF); 0.2mg/kg body weight subcutaneous ivermectin (IVM); a combination of TCF+IVM at the same doses and administration routes; or remained untreated (control group). All calves were necropsied at day 14 post treatment for counting and identification of worms from abomasum, small and large intestines and lungs to determine the absolute efficacy (controlled efficacy test) for each treatment. Using the faecal egg count reduction test, the efficacy was 63.7 % for TCF, 72.3 % for IVM and 99.2 % for TCF+IVM. The absolute efficacy of IVM and IVM+TCF was 100 % against Haemonchus placei, Trichostrongylus axei and Ostertagia ostertagi (p < 0.05). TCF showed a similar level of efficacy except against O. ostertagi (84.7 %). Efficacy of the treatments against Cooperia oncophora/pectinata/mcmasteri was 80.4 % for IVM, 95.7 % for TCF and 99.6 % for TCF+IVM; against Trichostrongylus colubriformis was 79 % for IVM, 86.2 % for TCF and 94.1 % for TCF+IVM; against Nematodirus helvetianus was 0 % for IVM, 100 % for TCF and 93.8 % for TCF+IVM. The efficacies of TCF, IVM and TCF+IVM were 100 % against Oesophagostomum radiatum and Trichuris spp. The efficacy of TCF against Dictyocaulus viviparus was 52 % and 100 % for IVM and IVM+TCF, respectively. This is the first report of Trichostrongylus colubriformis and Nematodirus helvetianus resistant to ivermectin treatment in cattle of Argentina. The TCF+IVM combination could be an alternative for the control and treatment of nematode infections including IVM-resistant strains. Springer-Verlag, 2011 Fiel César Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut Guzmán Maricel Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut Steffan Pedro Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut Prieto Olegario Bayer HealthCare, Animal Health Division, Munro, Argentina aut Bhushan Chandra Bayer HealthCare, Animal Health Division, Monheim, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 105-112 0932-0113 109<105 2011 109 436 https://doi.org/10.1007/s00436-011-2407-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2407-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fiel César Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut NATIONALLICENCE 700 1- Guzmán Maricel Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut NATIONALLICENCE 700 1- Steffan Pedro Área de Parasitología, Facultad de Ciencias Veterinarias, UNCPBA, Tandil, Argentina aut NATIONALLICENCE 700 1- Prieto Olegario Bayer HealthCare, Animal Health Division, Munro, Argentina aut NATIONALLICENCE 700 1- Bhushan Chandra Bayer HealthCare, Animal Health Division, Monheim, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 105-112 0932-0113 109<105 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer