caa a22 4500 445340576 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2411-7 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2411-7 Efficacy and Safety of the Combination Imidacloprid 10 % [Elektronische Daten] moxidectin 1.0 % Spot-on (Advocate® Spot-on for Small Cats and Ferrets) in the Treatment of Ear Mite Infection ( Otodectes cynotis ) in Ferrets / [Christophe Le Sueur, Sophie Bour, Roland Schaper] In this study, the efficacy and safety of a treatment with the combination imidacloprid 10 %/ moxidectin 1.0 % spot-on (Advocate® spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis). The study was performed as a multicentre, non-randomised, non-controlled (all study animals were treated) and non-blinded clinical field study in two French veterinary practices. Four visits (day (D) 0 = inclusion and first treatment, D14 = second treatment, D28 = possible third treatment, D56 = termination) were planned. The dosage was one pipet per ferret (designed for cats weighing up to 4kg, corresponding to a dose of moxidectin ranging from 2.2 to 5mg/kg body weight) two or three times at 14-days intervals (at D0, D14 and possibly D28 depending on the parasitological examination of the ears at D28). The main efficacy criterion was the absence of the parasite (all stages incl. eggs, larvae, nymphs and adults) from ear scrapings by microscopic examination. At D28 after two treatments (D0 and D14), 76.9 % (30/39) of animals were cured. Only 23 % (9/39) needed a third treatment. At day 56, 100 % were cured. Local symptoms (inflammation and pruritus) were consistently improved (50.6 % improvement at D14, 81.0 % at D28 and 97.9 % at D56) as well as the abnormal cerumen production (14.7 % improvement at D14, 77.7 % at D28 and 100.0 % at D56). No general symptoms were noticed during the study (general health and skin aspect). Advocate® spot-on for small cats and ferrets is an effective and safe treatment for ear mite infection in ferrets. Two or three treatments administered in 14-days intervals to ferrets infested with ear mites provided 100 % parasitological cure on D56. The Author(s), 2011 Le Sueur Christophe Bayer Santé Division Santé Animale, Puteaux, France aut Bour Sophie Bayer Santé Division Santé Animale, Puteaux, France aut Schaper Roland Bayer Animal Health GmbH, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 149-156 0932-0113 109<149 2011 109 436 https://doi.org/10.1007/s00436-011-2411-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2411-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Sueur Christophe Bayer Santé Division Santé Animale, Puteaux, France aut NATIONALLICENCE 700 1- Bour Sophie Bayer Santé Division Santé Animale, Puteaux, France aut NATIONALLICENCE 700 1- Schaper Roland Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 149-156 0932-0113 109<149 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer