caa a22 4500 445340584 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2400-x doi (NATIONALLICENCE)springer-10.1007/s00436-011-2400-x Efficacy of Emodepside/Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Mixed Experimental Isospora felis/Isospora rivolta Infection in Cats [Elektronische Daten] [Gabriele Petry, Eva Kruedewagen, Andreas Kampkoetter, Klemens Krieger] The coccidia Isospora felis and Isospora rivolta are intestinal parasites occurring worldwide in domestic cats. In young cats, they can be detected with higher prevalence. The effects of toltrazuril in the new combination product Procox® oral suspension for dogs containing 0.1 % emodepside and 2 % toltrazuril (0.9mg emodepside + 18mg toltrazuril per ml) were studied in eighteen kittens experimentally infected each with a total of 1 x 105 oocysts of a mixture of Isospora felis and Isospora rivolta. In the infectious material, the quantitative relation of I. felis and I. rivolta was about 1:5. Following a three-days period after infection, two groups of 6 kittens were treated during the prepatent period with either a single dose of 0.45mg emodepside + 9mg toltrazuril/kg body weight or 0.9mg emodepside + 18mg toltrazuril/kg body weight. A group of six kittens without any treatment served as a control. On day 5 post infection, the untreated kittens started the excretion of oocysts. Treatment with both toltrazuril doses significantly reduced oocyst excretion. Following the single higher dose, the reduction of oocysts of both Isospora spp. was more pronounced (96.7 % to 100 %) in comparison to the lower dose (57.2 % to 100 %). The Procox® application was well tolerated and no adverse events were seen with any of the applied dosages. When administered to kittens and as a single treatment during the prepatent period, Procox® is suitable to control the number of oocysts excreted in the faeces in case of an Isospora felis and Isospora rivolta infection. The Author(s), 2011 Petry Gabriele Bayer Animal Health GmbH, Leverkusen, Germany aut Kruedewagen Eva Bayer Animal Health GmbH, Leverkusen, Germany aut Kampkoetter Andreas Bayer Animal Health GmbH, Leverkusen, Germany aut Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 29-36 0932-0113 109<29 2011 109 436 https://doi.org/10.1007/s00436-011-2400-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2400-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petry Gabriele Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Kruedewagen Eva Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Kampkoetter Andreas Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 29-36 0932-0113 109<29 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer