caa a22 4500 445340630 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2398-0 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2398-0 Efficacy of Emodepside plus Toltrazuril Suspension (Procox® Oral Suspension for Dogs) against Prepatent and Patent Infection with Isospora canis and Isospora ohioensis -Complex in Dogs [Elektronische Daten] [Gertraut Altreuther, Nadine Gasda, Iris Schroeder, Anja Joachim, Terry Settje, Annette Schimmel, Douglas Hutchens, Klemens Krieger] Three randomised, blinded and placebo-controlled laboratory studies were conducted to evaluate the efficacy of emodepside plus toltrazuril suspension (Procox® suspension for dogs) against Isospora canis and Isospora ohioensis-complex. Unweaned puppies were experimentally infected with sporulated oocysts of I. canis and/or I. ohioensis-complex. In each study, one group was treated during prepatency (2 or 4days post infection) while dogs in the second group were treated individually after the onset of oocyst excretion of the respective coccidia species. The dogs were treated with the minimum therapeutic dose of 0.45mg emodepside and 9mg toltrazuril per kg body weight. Daily faecal oocyst counts from both groups were compared to placebotreated control groups to determine efficacy. Dogs treated during prepatent I. canis or I. ohioensis-complex infection showed significantly lower oocyst counts for up to 12days compared to the control group. Oocyst counts were reduced by 90.2 - 100 % while the control groups continued to exhibit an adequate infection, except for one study where efficacy against prepatent I. canis infection faded 13days after treatment. Following treatment of patent I. canis or I. ohioensis-complex infections, significantly lowered oocyst counts were observed for up to 9days compared to the control group. Faecal oocyst counts were reduced by 91.5 - 100 %. In all three studies the number of days with diarrhoea was significantly lower when dogs were treated during prepatent Isospora spp. infection compared to the control groups. No adverse drug reactions were observed during the studies. In conclusion, the studies demonstrated that emodepside plus toltrazuril suspension is an efficient coccidiocide for dogs. The Author(s), 2011 Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut Gasda Nadine Bayer Animal Health GmbH, Leverkusen, Germany aut Schroeder Iris Bayer Animal Health GmbH, Leverkusen, Germany aut Joachim Anja Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria aut Settje Terry Bayer HealthCare LLC, Shawnee Mission, KS, USA aut Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 9-20 0932-0113 109<9 2011 109 436 https://doi.org/10.1007/s00436-011-2398-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2398-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Gasda Nadine Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Schroeder Iris Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Joachim Anja Institute of Parasitology, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Settje Terry Bayer HealthCare LLC, Shawnee Mission, KS, USA aut NATIONALLICENCE 700 1- Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 9-20 0932-0113 109<9 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer