caa a22 4500 445340657 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2397-1 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2397-1 Efficacy of Emodepside plus Toltrazuril (Procox® Oral Suspension for Dogs) against Toxocara canis , Uncinaria stenocephala and Ancylostoma caninum in Dogs [Elektronische Daten] [Annette Schimmel, Iris Schroeder, Gertraut Altreuther, Terry Settje, Samuel Charles, Sonja Wolken, Dawid Kok, Jennifer Ketzis, David Young, Douglas Hutchens, Klemens Krieger] The efficacy of emodepside plus toltrazuril (Pro-and between 4 and 655 worms for hookworms. The cox® oral suspension for dogs) against different studies demonstrated 100 % efficacy of emodepside/ species of gastrointestinal nematodes (Toxocara toltrazuril suspension against mature adult, ≥94.7% canis, Ancylostoma caninum, Uncinaria steno-efficacy against immature adult and 99.3 % efficacy cephala) was evaluated in nine randomised, against the L4 larval stage of T. canis. The efficacy blinded and placebo-controlled laboratory studies against mature adult A. caninum was ≥ 99.5 % and in naturally or experimentally infected dogs. The the efficacy against mature adult U. stenocephala product was used at the proposed minimum dose was 100 %. All differences between treatment and of 0.45mg emodepside and 9mg toltrazuril per control groups were statistically significant and no kg body weight. Efficacy was calculated based on gender effect was found. It can be concluded that the worm counts after necropsy. Worm burdens in the control dogs ranged between 0 and 409 worms of the respective stage for T. canis and between 4 and 655 worms for hookworms. The studies demonstrated 100 % efficacy of emodepside/toltrazuril suspension against mature adult, ≥ 94.7 % efficacy against immature adult and 99.3 % efficacy against the L4 larval stage of T. canis. The efficacy against mature adult A. caninum was ≥ 99.5 % and the efficacy against mature adult U. stenocephala was 100 %. All differences between treatment and control groups were statistically significant and no gender effect was found. It can be concluded that the emodepside/toltrazuril suspension represents a safe and highly effective product in dogs with nematode (T. canis, hookworms) infection. The Author(s), 2011 Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut Schroeder Iris Bayer Animal Health GmbH, Leverkusen, Germany aut Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut Settje Terry Bayer HealthCare LLC, Shawnee Mission, KS, USA aut Charles Samuel Bayer HealthCare LLC, Shawnee Mission, KS, USA aut Wolken Sonja Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany aut Kok Dawid ClinVet International (Pty) Ltd., Bloemfontein, Republic of South Africa aut Ketzis Jennifer Charles River Laboratories Preclinical Services Ireland Co., Mayo, Ireland aut Young David Young Veterinary Research Services, Turlock, CA, USA aut Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 1-8 0932-0113 109<1 2011 109 436 https://doi.org/10.1007/s00436-011-2397-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2397-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Schroeder Iris Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Settje Terry Bayer HealthCare LLC, Shawnee Mission, KS, USA aut NATIONALLICENCE 700 1- Charles Samuel Bayer HealthCare LLC, Shawnee Mission, KS, USA aut NATIONALLICENCE 700 1- Wolken Sonja Institute for Parasitology, University of Veterinary Medicine Hannover, Hannover, Germany aut NATIONALLICENCE 700 1- Kok Dawid ClinVet International (Pty) Ltd., Bloemfontein, Republic of South Africa aut NATIONALLICENCE 700 1- Ketzis Jennifer Charles River Laboratories Preclinical Services Ireland Co., Mayo, Ireland aut NATIONALLICENCE 700 1- Young David Young Veterinary Research Services, Turlock, CA, USA aut NATIONALLICENCE 700 1- Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 1-8 0932-0113 109<1 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer