caa a22 4500 445340681 CHVBK 20180317142811.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2399-z doi (NATIONALLICENCE)springer-10.1007/s00436-011-2399-z Field Evaluations of the Efficacy and Safety of Emodepside plus Toltrazuril (Procox® Oral Suspension for Dogs) against Naturally Acquired Nematode and Isospora spp. Infections in Dogs [Elektronische Daten] [Gertraut Altreuther, Nadine Gasda, Kerstin Adler, Klaus Hellmann, Heloise Thurieau, Annette Schimmel, Douglas Hutchens, Klemens Krieger] Three controlled, blinded and randomised multicentre field studies evaluated the efficacy and safety of a new formulation containing emodepside plus toltrazuril (Procox® suspension for dogs) against naturally acquired parasite infections in dogs. In two studies dogs positive for gastrointestinal nematodes and/or Isospora spp. were treated with emodepside/toltrazuril suspension (at least 0.45mg emodepside plus 9mg toltrazuril per kg body weight) or a reference product containing either milbemycin oxime plus praziquantel (Milbemax®) or sulfadimethoxine (Kokzidiol SD®) at recommended dose rates. The third study investigated efficacy against prepatent natural Isospora spp. infections in comparison to an untreated control group by enrolling Isospora- negative dogs that were at risk to develop a patent infection during the study. No suspected adverse drug reactions were observed in any of the 403 dogs enrolled in the three studies including 234 dogs treated with emodepside/toltrazuril suspension. In dogs treated with emodepside/toltrazuril suspension against nematode infection faecal egg counts were reduced by 100 % (reference product: 99.7 %). Similarly, in the dogs that had been treated against patent Isospora spp. infection, faecal oocyst counts were reduced by 100 % (reference product: 99.0 %). In both studies, statistical analysis demonstrated non-inferiority and even superiority to the reference products (p ≤ 0.009). Dogs treated with emodepside/toltrazuril suspension during suspected prepatent Isospora spp. infection had 98.7 % lower faecal oocyst counts after treatment compared to untreated dogs (p < 0.0001). The studies demonstrated that emodepside/toltrazuril suspension is safe and highly efficacious against nematodes and Isospora spp. under field conditions. The Author(s), 2011 Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut Gasda Nadine Bayer Animal Health GmbH, Leverkusen, Germany aut Adler Kerstin Klifovet AG, Munich, Germany aut Hellmann Klaus Klifovet AG, Munich, Germany aut Thurieau Heloise Bayer Santé Division Santé Animale, Puteaux, France aut Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut Parasitology Research Springer-Verlag 109(2011-08-01), 21-28 0932-0113 109<21 2011 109 436 https://doi.org/10.1007/s00436-011-2399-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2399-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altreuther Gertraut Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Gasda Nadine Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Adler Kerstin Klifovet AG, Munich, Germany aut NATIONALLICENCE 700 1- Hellmann Klaus Klifovet AG, Munich, Germany aut NATIONALLICENCE 700 1- Thurieau Heloise Bayer Santé Division Santé Animale, Puteaux, France aut NATIONALLICENCE 700 1- Schimmel Annette Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Hutchens Douglas Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 700 1- Krieger Klemens Bayer Animal Health GmbH, Leverkusen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109(2011-08-01), 21-28 0932-0113 109<21 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer