caa a22 4500 445340843 CHVBK 20180317142812.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00436-011-2344-1 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2344-1 Antiplasmodial activity of artecyclopentyl mether a new artemisinin derivative and its effect on pathogenesis in Plasmodium yoelii nigeriensis infected mice [Elektronische Daten] [Jyoti Agarwal, Suriya Singh, Debabrata Chanda, Dnyaneshwar Bawankule, Rajendra Bhakuni, Anirban Pal] In an effort to evaluate novel derivatives from artemisinin, possessing potential antimalarial activity, a new derivative artecyclopentyl mether (CPM-1) was derivatized and evaluated for its dose-dependent efficacy in Plasmodium yoelii nigeriensis infected mice. The survivability of mice at 7.5mg/kg was >28days with negligible parasitaemia and recovered anemia (66.16-72.62%). Artecyclopentyl mether was also found to modulate the pro- and anti-inflammatory cytokines (IFN-γ, 39.64-56.92%; TNF, 49.10-74.31%; IL-4, 11.53-43.22%; IL-10, 37.60-53.52%) favourably besides optimizing the oxidative stress to the infected subjects as evident by the nitric oxide (88.76-95.43%), lipid peroxidation (59.30-76.05%) and glycaemic data (62.70-76.66%). The results indicate the potentiality of the new derivative as an antimalarial against asexual stages of the parasite. Springer-Verlag, 2011 Agarwal Jyoti Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Singh Suriya Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Chanda Debabrata Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Bawankule Dnyaneshwar Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Bhakuni Rajendra Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Pal Anirban Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut Parasitology Research Springer-Verlag 109/4(2011-10-01), 1003-1008 0932-0113 109:4<1003 2011 109 436 https://doi.org/10.1007/s00436-011-2344-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2344-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Agarwal Jyoti Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 700 1- Singh Suriya Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 700 1- Chanda Debabrata Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 700 1- Bawankule Dnyaneshwar Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 700 1- Bhakuni Rajendra Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 700 1- Pal Anirban Central Institute of Medicinal and Aromatic Plants, CSIR, P.O.CIMAP, 226015, Lucknow, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/4(2011-10-01), 1003-1008 0932-0113 109:4<1003 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer