caa a22 4500 445340878 CHVBK 20180317142812.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00436-011-2348-x doi (NATIONALLICENCE)springer-10.1007/s00436-011-2348-x An evolutionary analysis of trypanosomatid GP63 proteases [Elektronische Daten] [Lina Ma, Kaifu Chen, Qingshu Meng, Qingyou Liu, Petrus Tang, Songnian Hu, Jun Yu] The trypanosomatid GP63 proteases are known to be involved in parasite-host interaction and exhibit strong sequence and structural similarities to those of their hosts and insect vectors. Based on genome sequences of the three trypanosomatids, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., we annotated all their GP63 proteases and divided highly duplicated T. cruzi GP63 proteases into four novel groups according to sequence features. In Leishmania spp., we studied the evolutionary dynamics of GP63 proteins and identified 57 amino acid sites that are under significant positive selections. These sites may contribute to the functional variations of the GP63 proteases and provide clues for vaccine development. Springer-Verlag, 2011 Ma Lina CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut Chen Kaifu CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut Meng Qingshu CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut Liu Qingyou Animal Reproduction Institute, Guangxi Key Laboratory of Subtropical Bioresource Conservation and Utilization, Guangxi University, 530004, Nanning, People's Republic of China aut Tang Petrus Molecular Regulation and Bioinformatics Laboratory, Chang Gung University, 333, Taoyuan, Taiwan aut Hu Songnian CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut Yu Jun CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut Parasitology Research Springer-Verlag 109/4(2011-10-01), 1075-1084 0932-0113 109:4<1075 2011 109 436 https://doi.org/10.1007/s00436-011-2348-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2348-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ma Lina CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut NATIONALLICENCE 700 1- Chen Kaifu CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut NATIONALLICENCE 700 1- Meng Qingshu CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut NATIONALLICENCE 700 1- Liu Qingyou Animal Reproduction Institute, Guangxi Key Laboratory of Subtropical Bioresource Conservation and Utilization, Guangxi University, 530004, Nanning, People's Republic of China aut NATIONALLICENCE 700 1- Tang Petrus Molecular Regulation and Bioinformatics Laboratory, Chang Gung University, 333, Taoyuan, Taiwan aut NATIONALLICENCE 700 1- Hu Songnian CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut NATIONALLICENCE 700 1- Yu Jun CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No.7 Beitucheng West Road,, 100029, Beijing, Chaoyang District,, People's Republic of China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/4(2011-10-01), 1075-1084 0932-0113 109:4<1075 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer