caa a22 4500 445341033 CHVBK 20180317142812.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00436-011-2367-7 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2367-7 Expression of erythropoietic cytokines in α-tocopherol transfer protein knockout mice with murine malaria infection [Elektronische Daten] [Maria Herbas, Yoshiko Ueta, Kana Ishibashi, Hiroshi Suzuki] Malaria infection leads to anemia in humans which generally occurs during the chronic phase of the infection. The role that erythropoietic molecules play for anemia during malaria at low parasitemia levels is still controversial due to the lack of suitable animal models which might mimic this condition. In this regard, α-tocopherol transfer protein knockout mice, with undetectable levels of vitamin E in circulation, were possibly used as a model to investigate the role that erythropoietic molecules such as erythropoietin (EPO), erythropoietin receptor (EPOR), and macrophage migration inhibitory factor (MIF) play on the outcome of anemia during uncomplicated malaria infection at low parasitemias. The results indicate that the degree of parasitemia unlikely plays any important effect on mRNA expression of EPO and EPOR in different organs. Moreover, even though EPO and EPOR productions are impaired in the kidney and bone marrow, respectively, other organs such as the liver and spleen intend to compensate production of these cytokines to prevent anemia in the infected animals. Springer-Verlag, 2011 Herbas Maria Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut Ueta Yoshiko Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut Ishibashi Kana Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut Suzuki Hiroshi Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut Parasitology Research Springer-Verlag 109/5(2011-11-01), 1243-1250 0932-0113 109:5<1243 2011 109 436 https://doi.org/10.1007/s00436-011-2367-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2367-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herbas Maria Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut NATIONALLICENCE 700 1- Ueta Yoshiko Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut NATIONALLICENCE 700 1- Ishibashi Kana Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut NATIONALLICENCE 700 1- Suzuki Hiroshi Research Unit for Functional Genomics, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada, 080-8555, Obihiro, Japan aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/5(2011-11-01), 1243-1250 0932-0113 109:5<1243 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer