caa a22 4500 445341246 CHVBK 20180317142813.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00436-011-2433-1 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2433-1 Efficacy of ginkgolic acids against Cryptosporidium andersoni in cell culture [Elektronische Daten] [Liang Wu, Xu-gan Jiang, Yu-juan Shen, Zhao-xi Lu, Guo-hua Tu, Xing-li Fu, Sheng-xia Chen, Jian-ping Cao] Cryptosporidium is a worldwide waterborne parasite and the treatment is a severe problem in immunocompromised patients. In this study, we used the in vitro culture system to evaluate the anti-Cryptosporidium activity of ginkgolic acids (GAs), nitazoxanide (NTZ), garlicin (GAR), and artemether (ART). The growth of Cryptosporidium andersoni in HCT-8 cells was determined by real-time PCR assay. When exposed to 5.00μg/ml GAs or 10.00μg/ml NTZ for 48h, the number of C. andersoni in cultures was on a very low lever, but the number of parasites did not significantly decrease when exposed to GAR and ART. Our results indicate that GAs could be a potential drug for the treatment of cryptosporidiosis. Springer-Verlag, 2011 Wu Liang School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Jiang Xu-gan School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Shen Yu-juan National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Laboratory of Parasite and Vector Biology, MOH, Shanghai, People's Republic of China aut Lu Zhao-xi School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Tu Guo-hua School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Fu Xing-li School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Chen Sheng-xia School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut Cao Jian-ping National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Laboratory of Parasite and Vector Biology, MOH, Shanghai, People's Republic of China aut Parasitology Research Springer-Verlag 109/5(2011-11-01), 1475-1479 0932-0113 109:5<1475 2011 109 436 https://doi.org/10.1007/s00436-011-2433-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2433-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Liang School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Jiang Xu-gan School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Shen Yu-juan National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Laboratory of Parasite and Vector Biology, MOH, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Lu Zhao-xi School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Tu Guo-hua School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Fu Xing-li School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Chen Sheng-xia School of Medical Science and Laboratory Medicine, Jiangsu University, 212013, Zhenjiang, People's Republic of China aut NATIONALLICENCE 700 1- Cao Jian-ping National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Laboratory of Parasite and Vector Biology, MOH, Shanghai, People's Republic of China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/5(2011-11-01), 1475-1479 0932-0113 109:5<1475 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer