caa a22 4500 445341610 CHVBK 20180317142815.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00436-011-2474-5 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2474-5 Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum [Elektronische Daten] [Hong-Jun Li, Wei Wang, You-Zi Li, Guo-Li Qu, Yun-Tian Xing, Yong-Hui Tao, Jian-Ying Wei, Jian-Rong Dai, You-Sheng Liang] Artemether and artesunate, derivatives of the antimalarial artemisinin, as well as their main metabolite, dihydroartemisinin, all exhibit antischistosomal activities. The purpose of the current study was to compare the effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum. We carried out experiments with mice, infected with 40 cercariae of S. japonicum, and treated with artemether, aretesunate and dihydroartemisinin (all at a single dose of 300mg/kg, and the dose of the mixed three drugs is also 300mg/kg) at multiple doses or combination therapy on days 6-8 or 34-36 post-infection. Administration with artemether, artesunate or dihydroartemisinin for 3 successive days reduced total worm burdens by 79.5−86% (30.86 ± 4.98 of mean total worm burden in control), female worm burdens by 79.4−86.7% (11.29 ± 2.63 of mean female worm burden in control) (all P values <0.01 vs. control), depending on different treatment protocols given on days 6-8 post-infection. However, no differences were seen between each treatment group (all P > 0.05). While the same treatment was given on days 34-36 post-infection, total worm burden reductions of 73.8−75.8% were achieved (29.44 ± 3.36 of mean total worm burden in control), which were significant when compared with the untreated control group (all P values <0.01). In all different treatment groups, female worm reductions (ranging from 88.7% to 93.1%, while the mean female worm burden in control is 10.33 ± 1.80) were consistently higher than the total worm reductions, resulting always in significantly lower female worm burdens when compared to the corresponding control (all P values < 0.01). However, there were no significant differences found between each treatment group (all P values >0.05). It is concluded that artemether, artesunate and dihydroartemisinin can be used to control schistosomiasis japonica, as a strategy to prevent S. japonicum infection. Administration with artemether, artesunate and dihydroartemisinin at multiple doses or in combined treatment damages both juvenile and adult S. japonicum, without statistically significant differences among the three drugs at the same dose. Springer-Verlag, 2011 Li Hong-Jun Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Wang Wei Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Li You-Zi Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Qu Guo-Li Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Xing Yun-Tian Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Tao Yong-Hui Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Wei Jian-Ying Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Dai Jian-Rong Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Liang You-Sheng Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Parasitology Research Springer-Verlag 109/2(2011-08-01), 515-519 0932-0113 109:2<515 2011 109 436 https://doi.org/10.1007/s00436-011-2474-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2474-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Hong-Jun Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Wang Wei Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Li You-Zi Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Qu Guo-Li Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Xing Yun-Tian Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Tao Yong-Hui Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Wei Jian-Ying Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Dai Jian-Rong Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Liang You-Sheng Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 109/2(2011-08-01), 515-519 0932-0113 109:2<515 2011 109 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer