caa a22 4500 445341750 CHVBK 20180317142815.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00436-010-2039-z doi (NATIONALLICENCE)springer-10.1007/s00436-010-2039-z GC-MS analysis and antileishmanial activities of two Turkish propolis types [Elektronische Daten] [Nizami Duran, Mustafa Muz, Gulnaz Culha, Gulay Duran, Burcin Ozer] Propolis is a honeybee product with a very complex chemical composition and various pharmacological properties. This study was aimed to investigate antileishmanial activities of "Bursa” and "Hatay” propolis samples against Leishmania infantum and Leishmania tropica strains. Propolis samples were analysed with the gas chromatography-mass spectrometry technique. Promastigotes were incubated in Roswell Park Memorial Institute culture medium in the absence and presence of several concentrations (50, 100, 250, 500, 750, and 1,000μg/mL) of each propolis sample. The viability and cell morphology of promastigotes in each concentration were examined after 24, 48, 72, and 96h of incubation. The growth of leishmania parasites was significantly suppressed in the presence of 500, 750, and 1,000μg/mL of Hatay propolis. Bursa propolis was found to be efficient in inhibiting the growth of leishmania promastigotes in culture media at these concentrations, 250, 500, 750, and 1,000μg/mL. Thus, the in vitro results showed that the Hatay and Bursa propolis samples decreased significantly the proliferation of L. infantum and L. tropica parasites (p < 0.001); however, Bursa propolis was found to be more effective than Hatay propolis against leishmania promastigotes. These two natural products may be useful agents in the prevention of leishmanial infections. Springer-Verlag, 2010 Duran Nizami Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut Muz Mustafa Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut Culha Gulnaz Medical Faculty, Department of Parasitology, Mustafa Kemal University, Antakya, Turkey aut Duran Gulay Medical Faculty, Department of Medical Biology, Cukurova University, Antakya, Turkey aut Ozer Burcin Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut Parasitology Research Springer-Verlag 108/1(2011-01-01), 95-105 0932-0113 108:1<95 2011 108 436 https://doi.org/10.1007/s00436-010-2039-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2039-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duran Nizami Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut NATIONALLICENCE 700 1- Muz Mustafa Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut NATIONALLICENCE 700 1- Culha Gulnaz Medical Faculty, Department of Parasitology, Mustafa Kemal University, Antakya, Turkey aut NATIONALLICENCE 700 1- Duran Gulay Medical Faculty, Department of Medical Biology, Cukurova University, Antakya, Turkey aut NATIONALLICENCE 700 1- Ozer Burcin Medical Faculty, Department of Microbiology and Clinical Microbiology, Mustafa Kemal University, Antakya, Turkey aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/1(2011-01-01), 95-105 0932-0113 108:1<95 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer