caa a22 4500 445341912 CHVBK 20180317142816.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00436-010-2034-4 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2034-4 In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum [Elektronische Daten] [Asokan Bagavan, Abdul Rahuman, Naveen Kaushik, Dinkar Sahal] Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, ten plants were extracted with ethyl acetate and methanol and tested for their antimalarial activity against chloroquine (CQ)-sensitive (3D7) and CQ-resistant (Dd2 and INDO) strains of Plasmodium falciparum in culture using the fluorescence-based SYBR Green assay. Plant extracts showed moderate to good antiparasitic effects. Promising antiplasmodial activity was found in the extracts from two plants, Phyllanthus emblica leaf 50% inhibitory concentration (IC50) 3D7: 7.25μg/mL (ethyl acetate extract), 3.125μg/mL (methanol extract), and Syzygium aromaticum flower bud, IC50 3D7:13μg/mL, (ethyl acetate extract) and 6.25μg/mL (methanol extract). Moderate activity (30-75μg/mL) was found in the ethyl acetate and methanol extracts of Abrus precatorius (seed) and Gloriosa superba (leaf); leaf ethyl acetate extracts of Annona squamosa and flower of Musa paradisiaca. The above mentioned plant extracts were also found to be active against CQ-resistant strains (Dd2 and INDO). Cytotoxicity study with P. emblica leaf and S. aromaticum flower bud, extracts showed good therapeutic indices. These results demonstrate that leaf ethyl acetate and methanol extracts of P. emblica and flower bud extract of S. aromaticum may serve as antimalarial agents even in their crude form. The isolation of compounds from P. emblica and S. aromaticum seems to be of special interest for further antimalarial studies. Springer-Verlag, 2010 Bagavan Asokan Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam-632 509, Vellore District, Tamil Nadu, India aut Rahuman Abdul Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam-632 509, Vellore District, Tamil Nadu, India aut Kaushik Naveen Malaria Research Laboratory, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, 110067, New Delhi, India aut Sahal Dinkar Malaria Research Laboratory, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, 110067, New Delhi, India aut Parasitology Research Springer-Verlag 108/1(2011-01-01), 15-22 0932-0113 108:1<15 2011 108 436 https://doi.org/10.1007/s00436-010-2034-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2034-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bagavan Asokan Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam-632 509, Vellore District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Rahuman Abdul Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam-632 509, Vellore District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Kaushik Naveen Malaria Research Laboratory, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, 110067, New Delhi, India aut NATIONALLICENCE 700 1- Sahal Dinkar Malaria Research Laboratory, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, 110067, New Delhi, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/1(2011-01-01), 15-22 0932-0113 108:1<15 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer