caa a22 4500 445342102 CHVBK 20180317142816.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00436-010-2211-5 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2211-5 In vivo evaluation of anthelmintic potential of medicinal plant extracts against Dactylogyrus intermedius (Monogenea) in goldfish ( Carassius auratus ) [Elektronische Daten] [Zong-Fan Wu, Bin Zhu, Yong Wang, Cheng Lu, Gao-Xue Wang] In the present study, an attempt has been made to petroleum ether, chloroform, ethyl acetate, methanol, and water extracts of Prunus amygdalus Batsch seeds (Semen amygdali), Cimicifuga foetida L. rhizomes (Rhizoma Cimicifugae), Peucedanum decursivum (Miq.) Maxim roots (Radix Peucedani), Momordica cochinchinensis Spreng. seeds (Semen Momordicae), and Bupleurum chinense DC. roots (Radix Bupleuri chinensis) for their in vivo anthelmintic activity against monogenean Dactylogyrus intermedius in goldfish (Carassius auratus). The results showed that the efficacies of methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were found to be, in this order, more effective than others with the 48h-EC50 and EC90 values of 3.5 and 6.9, 6.0 and 8.4, 7.4 and 11.2mg/L, respectively, followed by ethyl acetate extract of R. cimicifugae and chloroform extract of R. peucedani with EC50 189.2 and 240.4mg/L. The promising methanol, chloroform, and ethyl acetate extracts from R. Bupleuri chinensis were subjected to acute toxicity tests for the evaluation of their safety to the host. After 48-h exposure, the mortalities of goldfish were recorded, and the established LC50 values were 10.1-, 4.2-, and 8.4-fold higher than the corresponding EC50. These results indicated that the three extracts from R. Bupleuri chinensis exhibit potential to be used as preferred natural antiparasitics for the control of the D. intermedius, especially for the methanolic one. Springer-Verlag, 2010 Wu Zong-Fan Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut Zhu Bin Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut Wang Yong Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut Lu Cheng Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut Wang Gao-Xue Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut Parasitology Research Springer-Verlag 108/6(2011-06-01), 1557-1563 0932-0113 108:6<1557 2011 108 436 https://doi.org/10.1007/s00436-010-2211-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2211-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Zong-Fan Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut NATIONALLICENCE 700 1- Zhu Bin Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut NATIONALLICENCE 700 1- Wang Yong Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut NATIONALLICENCE 700 1- Lu Cheng Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut NATIONALLICENCE 700 1- Wang Gao-Xue Northwest A&F University, No. 22 Xinong Road, 712100, Yangling, Shaanxi, China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/6(2011-06-01), 1557-1563 0932-0113 108:6<1557 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer