caa a22 4500 445342218 CHVBK 20180317142817.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00436-010-2184-4 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2184-4 Mangrove plants as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India [Elektronische Daten] [Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi, Malaiyandi Venkatesan, Andy Ramu] Malaria is the world's leading killer among the infectious diseases. The treatment of malaria is mystified by the challenges of widespread resistance of the malaria parasites to cheap and affordable antimalarial drugs. The present study was made in an attempt to identify the in vitro antiplasmodial activity against mangrove plant parts. (Avicennia marina, Acanthus ilicifolius, Bruguiera cylindrica, Excoecaria agallocha, Rhizophora apiculata, and Rhizophora mucronata mangrove plant extracts exhibited in vitro antiplasmodial activity against Plasmodium falciparum). Of the selected mangrove plant parts, the bark extract of A. marina exhibited minimum concentration of inhibitory activities IC50 49.63μg.ml−1. The leaf extract of A. marina, the hypocotyl extract of B. cylindrica, the leaf extract of E. agallocha, the flower extract of R. mucronata, and the hypocotyl extract of R. apiculata showed IC50 values between 50 and 100μg.ml−1. Statistical analysis reveals that significant antiplasmodial activity (P < 0.05) was observed between the concentrations and time of exposure. The chemical injury to erythrocytes was also carried out, and it shows that there were no morphological changes in erythrocytes by the ethanolic extract of mangrove plants after 48h of incubation. The in vitro antiplasmodial activity might be due to the presence of alkaloids, carboxylic acids, coumarins, saponins, flavonoids, xanthoproteins, tannins, phenols, sugars, resins, steroids, and proteins in the ethanolic extracts of mangrove plants. It is concluded from the present study that the ethanolic extracts of mangrove plant parts of A. marina possess lead compounds for the development of antiplasmodial drugs. Springer-Verlag, 2010 Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut Venkatesan Malaiyandi School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut Ramu Andy School of Chemistry, Department of Inorganic Chemistry, Madurai Kamaraj University, Madurai District, Tamil, Nadu, India aut Parasitology Research Springer-Verlag 108/6(2011-06-01), 1405-1410 0932-0113 108:6<1405 2011 108 436 https://doi.org/10.1007/s00436-010-2184-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2184-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut NATIONALLICENCE 700 1- Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut NATIONALLICENCE 700 1- Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut NATIONALLICENCE 700 1- Venkatesan Malaiyandi School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi, 623 409, Ramanathapuram District, Tamil, Nadu, India aut NATIONALLICENCE 700 1- Ramu Andy School of Chemistry, Department of Inorganic Chemistry, Madurai Kamaraj University, Madurai District, Tamil, Nadu, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/6(2011-06-01), 1405-1410 0932-0113 108:6<1405 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer