caa a22 4500 445342234 CHVBK 20180317142817.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00436-010-2185-3 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2185-3 In vitro antiplasmodial activity of ethanolic extracts of seaweed macroalgae against Plasmodium falciparum [Elektronische Daten] [Sundaram Ravikumar, Samuel Jacob Inbaneson, Palavesam Suganthi, Ramasamy Gokulakrishnan, Malaiyandi Venkatesan] Malaria is a major health problem in many developing countries. The drugs resistant Plasmodium falciparum causes the most virulent form of malaria in humans and it is described as a public health disaster causing increased morbidity and mortality. Thirteen seaweeds species which belong to four different families (Rhodomelaceae, Cladophoraceae, Ulvaceae, and Caulerpaceae) were collected from Mandapam coastal area and the seaweeds extracts were tested for in vitro antiplasmodial activity against P. falciparum. Among them, Caulerpa toxifolia (IC50 5.06μg·ml−1) showed potential antiplasmodial activity than other seaweeds extracts and it can be comparable with the positive control artemether (IC50 4.09μg·ml−1). Caulerpa peltata (IC50 16.69μg·ml−1) also exhibited good antiplasmodial activity and the IC50 value is lesser than the positive control chloroquine (IC50 19.59μg·ml−1). Statistical analysis reveals that significant in vitro antiplasmodial activity (P < 0.05) was observed between the concentrations and time of exposure. The chemical injury to erythrocytes was also carried out and it shows that no morphological changes in erythrocytes by the ethanolic extract of seaweeds extracts after 48h of incubation. The in vitro antiplasmodial activity might be due to the presence of sugars, proteins, and phenols in the ethanolic extracts of seaweeds. It is concluded from the present study that, the ethanolic extracts of seaweeds of C. toxifolia and C. peltata possesses lead compounds for development of antiplasmodial drugs. Springer-Verlag, 2010 Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut Gokulakrishnan Ramasamy School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut Venkatesan Malaiyandi School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut Parasitology Research Springer-Verlag 108/6(2011-06-01), 1411-1416 0932-0113 108:6<1411 2011 108 436 https://doi.org/10.1007/s00436-010-2185-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2185-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ravikumar Sundaram School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Jacob Inbaneson Samuel School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Suganthi Palavesam School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Gokulakrishnan Ramasamy School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 700 1- Venkatesan Malaiyandi School of Marine Sciences, Department of Oceanography and Coastal Area Studies, Alagappa University, Thondi Campus, Thondi—623 409, Ramanathapuram District, Tamil Nadu, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/6(2011-06-01), 1411-1416 0932-0113 108:6<1411 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer