caa a22 4500 445342471 CHVBK 20180317142818.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00436-010-2098-1 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2098-1 Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae [Elektronische Daten] [Josphat Matasyoh, Birger Dittrich, Anja Schueffler, Hartmut Laatsch] In a screening for natural products with mosquito larvicidal activities, the endophytic fungus Podospora sp. isolated from the plant Laggera alata (Asteraceae) was conspicuous. Two xanthones, sterigmatocystin (1) and secosterigmatocystin (2), and an anthraquinone derivative (3) 13-hydroxyversicolorin B were isolated after fermentation on M2 medium. These compounds were characterised using spectroscopic and X-ray analysis and examined against third instar larvae of Anopheles gambiae. The results demonstrated that compound 1 was the most potent one with LC50 and LC90 values of 13.3 and 73.5ppm, respectively. Over 95% mortality was observed at a concentration 100ppm after 24h. These results compared farvourably with the commercial larvicide pylarvex® that showed 100% mortality at the same concentration. Compound 3 was less potent and had an LC50 of 294.5ppm and over 95% mortality was achieved at a concentration of 1,000ppm. Secosterigmatocystin (2) revealed relatively weak activity and therefore LC values were not determined. The Author(s), 2010 Matasyoh Josphat Department of Chemistry, Egerton University, P. O. Box536, Egerton, Kenya aut Dittrich Birger Institute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077, Göttingen, Germany aut Schueffler Anja Institute for Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, 67663, Kaiserslautern, Germany aut Laatsch Hartmut Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany aut Parasitology Research Springer-Verlag 108/3(2011-03-01), 561-566 0932-0113 108:3<561 2011 108 436 https://doi.org/10.1007/s00436-010-2098-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2098-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matasyoh Josphat Department of Chemistry, Egerton University, P. O. Box536, Egerton, Kenya aut NATIONALLICENCE 700 1- Dittrich Birger Institute of Inorganic Chemistry, University of Göttingen, Tammannstrasse 4, 37077, Göttingen, Germany aut NATIONALLICENCE 700 1- Schueffler Anja Institute for Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, 67663, Kaiserslautern, Germany aut NATIONALLICENCE 700 1- Laatsch Hartmut Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, 37077, Göttingen, Germany aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/3(2011-03-01), 561-566 0932-0113 108:3<561 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer