caa a22 4500 445342668 CHVBK 20180317142818.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00436-011-2250-6 doi (NATIONALLICENCE)springer-10.1007/s00436-011-2250-6 Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth [Elektronische Daten] [Sanjeev Chandel, Upma Bagai] The rising problem of Plasmodium resistance to the classical antimalarial drugs stresses the need to look for newer antiplasmodial components with effective and new mode of action. In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy. The extract was found to possess significant in vitro antiplasmodial efficacy with an IC50 of 10.0μg/ml. Thus, the extract was further evaluated for its in vivo schizontocidal activity and efficacy in terms of survival time in Plasmodium berghei infected BALB/c mice. The extract at 250, 500, and 750mg/kg/day exhibited significant (p < 0.0001) blood schizontocidal activity during established infection with enhanced mean survival time comparable to that of standard drug chloroquine, 5mg/kg/day. The significant schizontocidal activity and enhanced mean survival time of mice stress the need to identify and characterize active antiplasmodial principle from this plant. Springer-Verlag, 2011 Chandel Sanjeev Parasitology Laboratory, Department of Zoology, Panjab University, 160014, Chandigarh, India aut Bagai Upma Parasitology Laboratory, Department of Zoology, Panjab University, 160014, Chandigarh, India aut Parasitology Research Springer-Verlag 108/4(2011-04-01), 801-805 0932-0113 108:4<801 2011 108 436 https://doi.org/10.1007/s00436-011-2250-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-011-2250-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chandel Sanjeev Parasitology Laboratory, Department of Zoology, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 700 1- Bagai Upma Parasitology Laboratory, Department of Zoology, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/4(2011-04-01), 801-805 0932-0113 108:4<801 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer