caa a22 4500 445342838 CHVBK 20180317142819.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00436-010-2197-z doi (NATIONALLICENCE)springer-10.1007/s00436-010-2197-z Another case of canine amoebic meningoencephalitis—the challenges of reaching a rapid diagnosis [Elektronische Daten] [Priscilla Hodge, Kylie Kelers, Robin Gasser, Govinda Visvesvara, Sandra Martig, Sam Long] A case of granulomatous amoebic meningoencephalitis in a previously healthy, mature, apparently immunocompetent dog, with a history of exposure to stagnant water, is reported. The case presented with ataxia and a tendency to fall to the left side. A computed tomography (CT) showed a ring-enhancing lesion within the cerebellum; an examination of cerebrospinal fluid (CSF) revealed nonspecific mixed-cell pleocytosis. Despite antibiotic and anti-inflammatory therapy, clinical signs progressed rapidly to decerebellate rigidity over 4days, and the dog was euthanased. Significant post-mortem findings were restricted to the brain, with a localised lytic lesion in the deep cerebellar white matter. Histopathological examination of the brain showed focally extensive cavitation of the white matter and communication of the lesion with the fourth ventricle. The affected area contained structures consistent with amoebae and was infiltrated by neutrophils mixed with lower numbers of macrophages, plasma cells and lymphocytes. The amoebae were identified as Balamuthia mandrillaris, based on specific immunofluorescence detection. Amoebic meningeoencephalitis should be considered in dogs with evidence of focal cavitary lesions in the brain, particularly in cases with a history of swimming in stagnant water. Springer-Verlag, 2010 Hodge Priscilla Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut Kelers Kylie Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut Gasser Robin Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut Visvesvara Govinda The Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Center for Disease Control and Prevention, Atlanta, GA, USA aut Martig Sandra Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut Long Sam Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut Parasitology Research Springer-Verlag 108/4(2011-04-01), 1069-1073 0932-0113 108:4<1069 2011 108 436 https://doi.org/10.1007/s00436-010-2197-z text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2197-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hodge Priscilla Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut NATIONALLICENCE 700 1- Kelers Kylie Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut NATIONALLICENCE 700 1- Gasser Robin Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut NATIONALLICENCE 700 1- Visvesvara Govinda The Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Center for Disease Control and Prevention, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Martig Sandra Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut NATIONALLICENCE 700 1- Long Sam Department of Veterinary Science, The University of Melbourne, Werribee, VIC, Australia aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/4(2011-04-01), 1069-1073 0932-0113 108:4<1069 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer