caa a22 4500 445343060 CHVBK 20180317142820.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00436-010-2199-x doi (NATIONALLICENCE)springer-10.1007/s00436-010-2199-x Zoonotic linkage and variation in Cryptosporidium parvum from patients in the United Kingdom [Elektronische Daten] [Rachel Chalmers, Richard Smith, Stephen Hadfield, Kristin Elwin, Michaela Giles] Relationships between patient exposure risks and variation within the Cryptosporidium parvum 60kDa glycoprotein (GP60) gene were explored in samples isolated from human cases of cryptosporidiosis (n = 69) in England and Wales. GP60 family IIa predominated (n = 56), followed by IId (n = 9). One case was IIc, a newly named genotype IIcA5G3j, and isolates from three cases did not amplify with the GP60 primers. Cases with GP60 family IIa were more likely than IId to have visited a farm, or had contact with farm animals or with their faeces in the 2weeks prior to illness. Within GP60 family IIa, genotypes IIaA15G2R1 and IIaA17G1R1 predominated (22 cases each); nine other IIa genotypes accounted for 12 cases. The IId genotypes were mainly IIdA17G1 and IIdA18G1 (3 each). Cases with IIaA17G1R1 were particularly linked to zoonotic exposures: visiting a farm or having farm animal contact in the 2weeks prior to illness. These findings provide further evidence of zoonotic pathways for the transmission of C. parvum isolates. Springer-Verlag, 2010 Chalmers Rachel UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut Smith Richard Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Addlestone, KT15 3NB, Surrey, UK aut Hadfield Stephen UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut Elwin Kristin UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut Giles Michaela Department of Food and Environmental Safety, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Addlestone, KT15 3NB, Surrey, UK aut Parasitology Research Springer-Verlag 108/5(2011-05-01), 1321-1325 0932-0113 108:5<1321 2011 108 436 https://doi.org/10.1007/s00436-010-2199-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2199-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chalmers Rachel UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut NATIONALLICENCE 700 1- Smith Richard Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Addlestone, KT15 3NB, Surrey, UK aut NATIONALLICENCE 700 1- Hadfield Stephen UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut NATIONALLICENCE 700 1- Elwin Kristin UK Cryptosporidium Reference Unit, Public Health Wales Microbiology, Singleton Hospital, SA2 8QA, Swansea, UK aut NATIONALLICENCE 700 1- Giles Michaela Department of Food and Environmental Safety, Veterinary Laboratories Agency, Weybridge, Woodham Lane, New Haw, Addlestone, KT15 3NB, Surrey, UK aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/5(2011-05-01), 1321-1325 0932-0113 108:5<1321 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer