caa a22 4500 445343273 CHVBK 20180317142820.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00436-010-2163-9 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2163-9 Artemether shows promising female schistosomicidal and ovicidal effects on the Egyptian strain of Schistosoma mansoni after maturity of infection [Elektronische Daten] [Rashad Abdul-Ghani, Naguiba Loutfy, Manal Sheta, Azza Hassan] Artemether is an artemisinin derivative that is used as an antimalarial drug, especially in situations where chloroquine resistance is suspected. This compound has proved to be a good prophylactic agent against schistosomiasis japonica in China. In the present study, the therapeutic efficacies of different artemether-dosing protocols were evaluated in experimentally infected mice harbouring adult Schistosoma mansoni (Egyptian strain). Mice were treated on day 46 onwards with three dosing protocols (400mg/kg/day for 2days; 200mg/kg/day for 4days; 100mg/kg/day for 6days) after being infected. A number of parasitological and histopathological criteria were employed in the assessment of drug efficacies compared to infected untreated control 2weeks post-treatment. The results of the present study suggest that artemether is efficacious against the Egyptian strain of S. mansoni with total worm reductions ranging from 40.7% to 59.7% and female worm reductions ranging from 69.3% to >90%. In addition, artemether induced significant reductions, ranging from 75.2% to 82.6%, in the liver tissue egg loads as well as significant reductions, ranging from 68.8% to 78.9% in the intestinal wall egg loads. It also induced significant alterations in the oogram pattern in the intestinal mucosa of infected mice with cessation of oviposition and increased rates of dead eggs. Antipathologic activities were also evident in the amelioration of granulomas in the liver with increased ratios of healed to active ones. In conclusion, artemether could be a promising agent in the control of schistosomiasis mansoni due to its schistosomicidal effects on female worms and to its ovicidal power as well as its potentiality in the improvement of hepatic lesions. Springer-Verlag, 2010 Abdul-Ghani Rashad Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen aut Loutfy Naguiba Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt aut Sheta Manal Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt aut Hassan Azza Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt aut Parasitology Research Springer-Verlag 108/5(2011-05-01), 1199-1205 0932-0113 108:5<1199 2011 108 436 https://doi.org/10.1007/s00436-010-2163-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2163-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abdul-Ghani Rashad Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen aut NATIONALLICENCE 700 1- Loutfy Naguiba Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- Sheta Manal Department of Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 700 1- Hassan Azza Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/5(2011-05-01), 1199-1205 0932-0113 108:5<1199 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer