caa a22 4500 445343559 CHVBK 20180317142821.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00436-010-2089-2 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2089-2 Effect of CD4+CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum [Elektronische Daten] [Chun-lian Tang, Jia-hui Lei, Tin Wang, Sheng-jun Lu, Fei Guan, Wen-qi Liu, Yong-long Li] It has been known that parasites developed sophisticated strategies to escape from the host immune assault. More recently, one strategy to induce immune evasion involved CD4+CD25+ regulatory T cells (Tregs). Mice were infected with Schistosoma japonicum cercariae and then injected intraperitoneally with anti-CD25 monoclonal antibody (anti-CD25 mAb). The results showed that the percentages of CD4+CD25+ Tregs in mice were expanded by S. japonicum infection, and it could be partially blocked by anti-CD25 mAb. Worm burden in anti-CD25 mAb group (23.17 ± 6.94) was significantly lower than that in infected group (30.17 ± 5.85). The level of interferon gamma was increased with anti-CD25 mAb administration; meanwhile, lower concentration of interleukin 10 was observed in the same group. These results suggest that CD4+CD25+ Tregs contribute to the escape of S. japonicum from the host immune responses, while anti-CD25 mAb can partially block CD4+CD25+ Tregs and enhance the protective immunity to the parasite by Th1-type immune response. Springer-Verlag, 2010 Tang Chun-lian Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Lei Jia-hui Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Wang Tin Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Lu Sheng-jun Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Guan Fei Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Liu Wen-qi Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Li Yong-long Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut Parasitology Research Springer-Verlag 108/2(2011-02-01), 477-480 0932-0113 108:2<477 2011 108 436 https://doi.org/10.1007/s00436-010-2089-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2089-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tang Chun-lian Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Lei Jia-hui Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Wang Tin Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Lu Sheng-jun Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Guan Fei Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Liu Wen-qi Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 700 1- Li Yong-long Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, 430030, Wuhan, China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/2(2011-02-01), 477-480 0932-0113 108:2<477 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer