caa a22 4500 445343621 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00436-010-2075-8 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2075-8 Up-regulation of lipophorin (Lp) and lipophorin receptor (LpR) gene in the mosquito, Culex quinquefasciatus (Diptera: Culicidae), infected with the filarial parasite, Wuchereria bancrofti (Spirurida: Onchocercidae) [Elektronische Daten] [B. Kumar, K. Paily] In mosquitoes, including Culex quinquefasciatus, immune molecules are known to be upregulated or produced de novo upon exposure to parasites or pathogens. These molecules are regulatory in nature acting against parasite or pathogen infection and development. Similarly, there are molecules that are upregulated to facilitate parasite development in the vector mosquitoes. Lipophorin, a major lipid transporting lipoprotein in the hemolymph of insects, is implicated as a helper molecule in the clotting mechanism and facilitator of parasite and pathogen development in mosquitoes. In the present study, upregulation of a 240kDa protein was detected in C. quinquefasciatus infected with the human lymphatic filarial parasite, Wuchereria bancrofti. It was identified as a lipophorin through nano-Lc-MS/MS analysis. Transcription of the lipophorin receptor gene also was identified through RACE-PCR. C. quinquefasciatus is the vector of W. bancrofti, and it allows successful development of the parasite. The role of upregulated lipophorin and transcription of its receptor gene in this mosquito could be implicated as a facilitator for the parasite development. Springer-Verlag, 2010 Kumar B. Vector Control Research Centre (Indian Council of Medical Research), 605006, Indira Nagar, Pondicherry, India aut Paily K. Vector Control Research Centre (Indian Council of Medical Research), 605006, Indira Nagar, Pondicherry, India aut Parasitology Research Springer-Verlag 108/2(2011-02-01), 377-381 0932-0113 108:2<377 2011 108 436 https://doi.org/10.1007/s00436-010-2075-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2075-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kumar B. Vector Control Research Centre (Indian Council of Medical Research), 605006, Indira Nagar, Pondicherry, India aut NATIONALLICENCE 700 1- Paily K. Vector Control Research Centre (Indian Council of Medical Research), 605006, Indira Nagar, Pondicherry, India aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/2(2011-02-01), 377-381 0932-0113 108:2<377 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer