caa a22 4500 445343648 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00436-010-2112-7 doi (NATIONALLICENCE)springer-10.1007/s00436-010-2112-7 Kinetics of circulating antigen 14-3-3 in sera of rabbits firstly infected with Schistosoma japonicum and treated with/without praziquantel [Elektronische Daten] [Chun-Yan Qian, Li-Jun Song, Wan-Quan Hua, Xu-Ren Yin, Jie Wang, Wei Zhang, Yong-Liang Xu, Chuan-Xin Yu] A sandwich ELISA was developed for the detection of circulating antigen 14-3-3 in the sera of rabbits. Rabbits that were infected with 500 cercariae of Schistosoma japonicum were grouped and the kinetics of 14-3-3 was observed. For the treated group, the 14-3-3 protein could be detected as early as 2-4weeks postinfection and then its levels rose rapidly and reached a peak at around 6weeks. The 14-3-3 levels in the sera significantly decreased after the infected rabbits were treated with praziquantel at 6weeks postinfection and declined to the initial level about 8weeks posttreatment. While in the untreated group, 14-3-3 levels reached a peak in 8weeks postinfection and then remained at plateau level for about 6weeks. Our findings showed that detection of S. japonicum14-3-3 has an important value for diagnosis of acute infection of S. japonicum and evaluation of chemotherapy. Springer-Verlag, 2010 Qian Chun-Yan Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Song Li-Jun Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Hua Wan-Quan Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Yin Xu-Ren Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Wang Jie Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Zhang Wei Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Xu Yong-Liang Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Yu Chuan-Xin Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut Parasitology Research Springer-Verlag 108/2(2011-02-01), 493-495 0932-0113 108:2<493 2011 108 436 https://doi.org/10.1007/s00436-010-2112-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00436-010-2112-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Qian Chun-Yan Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Song Li-Jun Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Hua Wan-Quan Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Yin Xu-Ren Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Wang Jie Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Zhang Wei Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Xu Yong-Liang Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 700 1- Yu Chuan-Xin Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, 214064, Wuxi, Jiangsu Province, China aut NATIONALLICENCE 773 0- Parasitology Research Springer-Verlag 108/2(2011-02-01), 493-495 0932-0113 108:2<493 2011 108 436 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer