caa a22 4500 445343699 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00406-010-0119-9 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0119-9 A morphometric analysis of the septal nuclei in schizophrenia and affective disorders: reduced neuronal density in the lateral septal nucleus in bipolar disorder [Elektronische Daten] [Ralf Brisch, Hans-Gert Bernstein, Henrik Dobrowolny, Dieter Krell, Renate Stauch, Kurt Trübner, Johann Steiner, Mounir Ghabriel, Hendrik Bielau, Rainer Wolf, Jana Winter, Siegfried Kropf, Tomasz Gos, Bernhard Bogerts] The septal nuclei are assumed to play a significant role in the pathophysiology of schizophrenia and affective disorders. The aim of this study was to morphometrically characterize the septal nuclei in patients with schizophrenia, bipolar disorder, and major depressive disorder, when compared with healthy control subjects. We analyzed the septal nuclei by determining the density and size of the neurons in postmortem brains in 17 patients with schizophrenia, 8 patients with bipolar disorder, 7 patients with major depressive disorder, and 14 control subjects matched for age and gender. There was a significant reduction in the neuronal density, but not in the mean cross-sectional area, in the lateral septal nucleus (P=0.013) in patients with bipolar disorder when compared with control subjects. There were no significant changes in the neuronal density of the septal nuclei of the medial and lateral cell groups in patients with schizophrenia and major depressive disorder when compared with control subjects. There was a significant negative correlation between neuronal density in the lateral septal nucleus and disease duration in patients with major depressive disorder (P=0.037, r=−0.9). The histopathological abnormality of the decreased neuronal density in the lateral septal nucleus, which is an important limbic region involved in emotions, might be a neuropathological correlate of bipolar disorder. Springer-Verlag, 2010 Septal nuclei nationallicence Neuroleptics nationallicence Bipolar disorder nationallicence Major depressive disorder nationallicence Brisch Ralf Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Bernstein Hans-Gert Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Dobrowolny Henrik Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Krell Dieter Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Stauch Renate Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Trübner Kurt Institute of Legal Medicine, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany aut Steiner Johann Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Ghabriel Mounir Department of Anatomical Sciences, University of Adelaide, 5005, Adelaide, Australia aut Bielau Hendrik Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Wolf Rainer LWL-Universitätsklinik Bochum, Alexandrinenstr.1, 44791, Bochum, Germany aut Winter Jana Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Kropf Siegfried Institute of Biometry and Medical Informatics, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut Gos Tomasz Institute of Forensic Medicine, Medical University of Gdansk, ul. Debowa 23, PL-80-204, Gdansk, Poland aut Bogerts Bernhard Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/1(2011-02-01), 47-58 0940-1334 261:1<47 2011 261 406 https://doi.org/10.1007/s00406-010-0119-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0119-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brisch Ralf Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Bernstein Hans-Gert Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Dobrowolny Henrik Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Krell Dieter Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Stauch Renate Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Trübner Kurt Institute of Legal Medicine, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany aut NATIONALLICENCE 700 1- Steiner Johann Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Ghabriel Mounir Department of Anatomical Sciences, University of Adelaide, 5005, Adelaide, Australia aut NATIONALLICENCE 700 1- Bielau Hendrik Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Wolf Rainer LWL-Universitätsklinik Bochum, Alexandrinenstr.1, 44791, Bochum, Germany aut NATIONALLICENCE 700 1- Winter Jana Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Kropf Siegfried Institute of Biometry and Medical Informatics, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 700 1- Gos Tomasz Institute of Forensic Medicine, Medical University of Gdansk, ul. Debowa 23, PL-80-204, Gdansk, Poland aut NATIONALLICENCE 700 1- Bogerts Bernhard Department of Psychiatry, Otto-von-Guericke-University of Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/1(2011-02-01), 47-58 0940-1334 261:1<47 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer