caa a22 4500 445343729 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00406-010-0133-y doi (NATIONALLICENCE)springer-10.1007/s00406-010-0133-y Negative schizophrenic symptoms and the frontal lobe syndrome: one and the same? [Elektronische Daten] [H. Ziauddeen, C. Dibben, C. Kipps, J. Hodges, P. McKenna] The negative symptoms of schizophrenia have been considered to be a psychiatric form of the frontal lobe syndrome. However, no studies have compared these two disorders at the clinical level. In this study, 12 negative symptom schizophrenic patients and 11 patients with behavioural variant frontotemporal dementia (bv-FTD) were rated for negative symptoms and for occurrence of frontal lobe behaviours in everyday life. They were also rated for speech disorder and were given a series of executive tests. Both patient groups showed positive ratings on negative symptoms and frontal lobe behaviours in daily life; however, the schizophrenic patients had higher negative symptom scores and the bv-FTD patients had higher carer ratings on frontal behaviours in daily life. Both groups were impaired on the executive tests, but the bv-FTD patients showed significantly greater impairment on verbal fluency and a test requiring inhibition of prepotent responses. A minority of the bv-FTD patients unexpectedly showed speech abnormalities typically associated with schizophrenia. The findings indicate that the negative syndrome in schizophrenia and the frontal lobe syndrome resemble each other clinically in important respects. Some of the differences may be attributable to the additional presence of disinhibition in the frontal lobe syndrome. Springer-Verlag, 2010 Schizophrenia nationallicence Frontal lobe syndrome nationallicence Frontotemporal dementia nationallicence Cognition nationallicence Ziauddeen H. Department of Psychiatry, University of Cambridge, Cambridge, UK aut Dibben C. Fulbourn Hospital, Cambridge, UK aut Kipps C. Wessex Neurological Centre, Southampton General Hospital, Southampton, UK aut Hodges J. Prince of Wales Medical Research Institute, Randwick, NSW, Australia aut McKenna P. Benito Menni CASM, Germanes Hospitalàries del Sagrat Cor de Jesús, C/Doctor Antoni Pujades 38-C, 08830, Barcelona, Spain aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/1(2011-02-01), 59-67 0940-1334 261:1<59 2011 261 406 https://doi.org/10.1007/s00406-010-0133-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0133-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ziauddeen H. Department of Psychiatry, University of Cambridge, Cambridge, UK aut NATIONALLICENCE 700 1- Dibben C. Fulbourn Hospital, Cambridge, UK aut NATIONALLICENCE 700 1- Kipps C. Wessex Neurological Centre, Southampton General Hospital, Southampton, UK aut NATIONALLICENCE 700 1- Hodges J. Prince of Wales Medical Research Institute, Randwick, NSW, Australia aut NATIONALLICENCE 700 1- McKenna P. Benito Menni CASM, Germanes Hospitalàries del Sagrat Cor de Jesús, C/Doctor Antoni Pujades 38-C, 08830, Barcelona, Spain aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/1(2011-02-01), 59-67 0940-1334 261:1<59 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer