caa a22 4500 44534377X CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00406-010-0182-2 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0182-2 Optimized voxel brain morphometry: association between brain volumes and the response to atypical antipsychotics [Elektronische Daten] [Vicente Molina, Carmen Martín, Alejandro Ballesteros, Alba de Herrera, Juan Hernández-Tamames] To date, few studies have addressed the relationship between brain structure alterations and responses to atypical antipsychotics in schizophrenia. To this end, in this study, magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) were used to assess the relationship between the brain volumes of gray (GM) and white (WM) matters and the clinical response to risperidone or olanzapine in 30 schizophrenia patients. In comparison with healthy controls, the patients in this study showed a bilateral decrease in the anteromedial cerebellar hemispheres, the rectal gyrus and the insula, together with bilateral increases in GM in the basal ganglia. Both patient groups had a significantly smaller volume of WM in a region encompassing the internal and external capsules as compared to the controls. We found an inverse association between striatal size and the degree of clinical improvement, and a direct association between the degree of insular volume deficit and its improvement. The non-responder patient group showed a significant decrease in their left rectal gyrus as compared with the responder group. This study reveals a pattern of structural alterations in schizophrenia associated with the response to risperidone or olanzapine. Springer-Verlag, 2010 Schizophrenia nationallicence Treatment-response nationallicence Voxel-based morphometry nationallicence Risperidone nationallicence Molina Vicente Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut Martín Carmen Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut Ballesteros Alejandro Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut de Herrera Alba Laboratorio de Imagen Médica, Universidad Rey Juan Carlos, Madrid, Spain aut Hernández-Tamames Juan Laboratorio de Imagen Médica, Universidad Rey Juan Carlos, Madrid, Spain aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 407-416 0940-1334 261:6<407 2011 261 406 https://doi.org/10.1007/s00406-010-0182-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0182-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molina Vicente Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut NATIONALLICENCE 700 1- Martín Carmen Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut NATIONALLICENCE 700 1- Ballesteros Alejandro Servicio de Psiquiatría, Hospital Universitario de Salamanca, Salamanca, Spain aut NATIONALLICENCE 700 1- de Herrera Alba Laboratorio de Imagen Médica, Universidad Rey Juan Carlos, Madrid, Spain aut NATIONALLICENCE 700 1- Hernández-Tamames Juan Laboratorio de Imagen Médica, Universidad Rey Juan Carlos, Madrid, Spain aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 407-416 0940-1334 261:6<407 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer