caa a22 4500 44534380X CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00406-011-0188-4 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0188-4 Excessive cannabis use is associated with earlier age at onset in bipolar disorder [Elektronische Daten] [Trine Lagerberg, Kjetil Sundet, Sofie Aminoff, Akiah Berg, Petter Ringen, Ole Andreassen, Ingrid Melle] The aim of the study was to investigate which factors are associated with age at onset in bipolar disorder with a specific focus on excessive alcohol and cannabis use, and the sequence of the onsets of excessive substance use and bipolar disorder. We investigated a naturalistic sample of 151 patients with bipolar I and II disorder receiving psychiatric treatment. Whether the presence of excessive substance use prior to bipolar disorder onset or the type of substance used (alcohol or cannabis) was associated with differences in age at onset was investigated using hierarchical and multiple linear regression analyses, adjusting for potential confounders. Patients with excessive alcohol use had a significantly later onset compared with patients with excessive cannabis use. Excessive general substance use prior to bipolar disorder onset was associated with a later onset. However, excessive cannabis use was associated with an earlier onset whether it preceded or followed bipolar disorder onset, also after adjusting for possible confounders. Excessive use of alcohol or other substances was not independently associated with age at onset in multivariate analyses. Alcohol use was associated with a later onset compared with cannabis use, suggesting different relationships to the onset of bipolar disorder. Lifetime use of cannabis predicted an earlier onset, independent of the sequence of onsets. This indicates that an early onset may increase the risk of cannabis use and that cannabis use may trigger bipolar disorder in vulnerable individuals. The Author(s), 2011 Bipolar disorder nationallicence Age at onset nationallicence Cannabis nationallicence Lagerberg Trine Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut Sundet Kjetil Department of Psychology, University of Oslo, Oslo, Norway aut Aminoff Sofie Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut Berg Akiah Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut Ringen Petter Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut Andreassen Ole Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut Melle Ingrid Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 397-405 0940-1334 261:6<397 2011 261 406 https://doi.org/10.1007/s00406-011-0188-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0188-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lagerberg Trine Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Sundet Kjetil Department of Psychology, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Aminoff Sofie Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Berg Akiah Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Ringen Petter Department of Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway aut NATIONALLICENCE 700 1- Andreassen Ole Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Melle Ingrid Psychosis Research Unit, Department of Research and Development, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 397-405 0940-1334 261:6<397 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer