caa a22 4500 445343818 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00406-010-0184-0 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0184-0 A visual [18F]FDG-PET rating scale for the differential diagnosis of frontotemporal lobar degeneration [Elektronische Daten] [Stefan Poljansky, Bernd Ibach, Barbara Hirschberger, Peter Männer, Hans Klünemann, Göran Hajak, Jörg Marienhagen] This study presents a visual rating scale for the assessment of cerebral [18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scans to characterize typical findings in dementias associated with frontotemporal lobar degeneration (FTLD) and to differentiate individual patients with FTLD compared to Alzheimer's disease (AD) and mild cognitive impairment (MCI). A total of 43 cerebral PET scans from patients with FTLD (n=16, mean age 58.4years), AD (n=16, 59.9years) and MCI (n=11, 57.9years) were analysed. Every PET data set was visually rated for seven brain regions on each hemisphere (frontal lobe, temporal lobe, parietal lobe, occipital lobe, basal ganglia, thalamus and cerebellum). The extent of the impairment in metabolism was classified as absent, mild, medium or strong. Using this four-stage visual rating scale, characteristic profiles of metabolic impairment in FTLD, AD, MCI and the FTLD-subgroup FTD (n=9) could be demonstrated. Patients with FTLD showed a significantly lower metabolism in the left frontal lobe and in the left basal ganglia when compared to AD and to MCI. Complementary analyses using statistical parametric mapping (SPM2) supported the findings of the visual analysis. In detecting FTLD with visual rating, sensitivity/specificity was 81/94% compared to AD and 81/64% compared to MCI. Patients with FTD were correctly attributed to a diagnosis of FTLD with a sensitivity of 89%. This visual rating scale may facilitate the differential diagnosis of FTLD in clinical routine. Springer-Verlag, 2011 Positron emission tomography nationallicence Frontotemporal lobar degeneration nationallicence Semantic dementia nationallicence Progressive aphasia nationallicence Early-onset Alzheimer's disease nationallicence Presenile dementia nationallicence Poljansky Stefan Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut Ibach Bernd Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut Hirschberger Barbara Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut Männer Peter Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut Klünemann Hans Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut Hajak Göran Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut Marienhagen Jörg Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 433-446 0940-1334 261:6<433 2011 261 406 https://doi.org/10.1007/s00406-010-0184-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0184-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Poljansky Stefan Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Ibach Bernd Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Hirschberger Barbara Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Männer Peter Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Klünemann Hans Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Hajak Göran Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstrasse 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Marienhagen Jörg Department of Nuclear Medicine, University of Regensburg, 93053, Regensburg, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/6(2011-09-01), 433-446 0940-1334 261:6<433 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer