caa a22 4500 445343842 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00406-011-0198-2 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0198-2 Prefrontal cortex gyrification index in twins: an MRI study [Elektronische Daten] [Alkomiet Hasan, Andrew McIntosh, Uta-Aglaia Droese, Thomas Schneider-Axmann, Stephen Lawrie, Thomas Moorhead, Ralf Tepest, Wolfgang Maier, Peter Falkai, Thomas Wobrock] Cortical development and folding seems to be under environmental as well as genetic control. The aim of our study was to estimate the genetic influence on gyrification and cortical volumes, comparing prefrontal gyrification index (GI) in monozygotic (MZ) and dizygotic (DZ) twin pairs, and unrelated pairs. Twenty-four subjects (6 pairs of MZ and 6 pairs of DZ twins) were included in this study. Prefrontal cortical folding (gyrification) was measured by an automated and manual version of the gyrification index (A-GI, M-GI) according to previously published protocols. MR-imaging was performed and 3 representative slices were selected from coronar MR-imaging scans. The volumes of the total brain, temporal lobes, prefrontal lobes, and cerebellum were analyzed, too. To evaluate similarity in GI, absolute differences in GI, and brain volumes as well as intraclass correlations of twin pairs were compared with regard to twin status. Finally, a control group of unrelated pairs was assembled from the first two study groups and analyzed. Compared to unrelated pairs, twin pairs exhibited more similarity concerning different brain volumes and a trend to more similarity concerning A-GI. MZ twins did not present more similarity concerning GI (automatically and manually measured) and volume measurements compared to DZ twins. Different factors, like intrauterine factors, postnatal development conditions, and especially environmental factors might account for the differences between related and unrelated pairs. The nonexistence of a pronounced similarity in MZ twins compared to DZ twins concerning prefrontal GI raises questions about the extent of genetic influence on GI. The Author(s), 2011 Twins nationallicence Cortical folding nationallicence Genetics nationallicence Gyrification nationallicence Prefrontal lobes nationallicence Hasan Alkomiet Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut McIntosh Andrew Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut Droese Uta-Aglaia Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Schneider-Axmann Thomas Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Lawrie Stephen Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut Moorhead Thomas Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut Tepest Ralf Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, German aut Maier Wolfgang Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany aut Falkai Peter Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Wobrock Thomas Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 459-465 0940-1334 261:7<459 2011 261 406 https://doi.org/10.1007/s00406-011-0198-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0198-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hasan Alkomiet Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- McIntosh Andrew Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut NATIONALLICENCE 700 1- Droese Uta-Aglaia Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Schneider-Axmann Thomas Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Lawrie Stephen Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut NATIONALLICENCE 700 1- Moorhead Thomas Department of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom aut NATIONALLICENCE 700 1- Tepest Ralf Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, German aut NATIONALLICENCE 700 1- Maier Wolfgang Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany aut NATIONALLICENCE 700 1- Falkai Peter Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Wobrock Thomas Department of Psychiatry and Psychotherapy, Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 459-465 0940-1334 261:7<459 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer