caa a22 4500 445343869 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00406-011-0208-4 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0208-4 EEG alterations during treatment with olanzapine [Elektronische Daten] [Detlef Degner, Michael Nitsche, Frank Bias, Eckart Rüther, Udo Reulbach] The aim of this naturalistic observational study was to investigate EEG alterations in patients under olanzapine treatment with a special regard to olanzapine dose and plasma concentration. Twenty-two in-patients of a psychiatric university ward with the monodiagnosis of paranoid schizophrenia (ICD-10: F20.0), who received a monotherapy of olanzapine were included in this study. All patients had a normal alpha-EEG before drug therapy, and did not suffer from brain-organic dysfunctions, as verified by clinical examination and cMRI scans. EEG and olanzapine plasma levels were determined under steady-state conditions (between 18 and 22days after begin of treatment). In 9 patients (40.9%), pathological EEG changes (one with spike-waves) consecutive to olanzapine treatment were observed. The dose of olanzapine was significantly higher in patients with changes of the EEG than in patients without changes (24.4mg/day (SD: 8.1) vs. 12.7mg/day (SD: 4.8); T=−4.3, df=21, P<0.001). In patients with EEG changes, the blood plasma concentration of olanzapine (45.6μg/l (SD: 30.9) vs. 26.3μg/l (SD: 21.6) tended to be also higher. The sensitivity of olanzapine dosage to predict EEG changes was 66.7%, the specificity 100% (Youden-index: 0.67). EEG abnormalities during olanzapine treatment are common. These are significantly dose dependent. Thus, EEG control recordings should be mandatory during olanzapine treatment with special emphasis on dosages exceeding 20mg per day, although keeping in mind that EEGs have only a limited predictive power regarding future epileptic seizures. Springer-Verlag, 2011 Psychopharmacology nationallicence Schizophrenia nationallicence Antipsychotic drugs nationallicence Olanzapine nationallicence EEG nationallicence Seizure nationallicence Degner Detlef Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut Nitsche Michael Department of Clinical Neurophysiology, Georg-August University of Goettingen, Goettingen, Germany aut Bias Frank Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut Rüther Eckart Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut Reulbach Udo Department of Public Health and Primary Care, Trinity College Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 483-488 0940-1334 261:7<483 2011 261 406 https://doi.org/10.1007/s00406-011-0208-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0208-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Degner Detlef Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Nitsche Michael Department of Clinical Neurophysiology, Georg-August University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Bias Frank Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Rüther Eckart Department of Psychiatry and Psychotherapy, Georg-August University of Goettingen, Goettingen, Germany aut NATIONALLICENCE 700 1- Reulbach Udo Department of Public Health and Primary Care, Trinity College Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 483-488 0940-1334 261:7<483 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer