caa a22 4500 445343885 CHVBK 20180317142822.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00406-011-0202-x doi (NATIONALLICENCE)springer-10.1007/s00406-011-0202-x Correlations between ventricular enlargement and gray and white matter volumes of cortex, thalamus, striatum, and internal capsule in schizophrenia [Elektronische Daten] [Guillermo Horga, Javier Bernacer, Nicola Dusi, Jonathan Entis, Kingwai Chu, Erin Hazlett, M. Mehmet Haznedar, Eileen Kemether, William Byne, Monte Buchsbaum] Ventricular enlargement is one of the most consistent abnormal structural brain findings in schizophrenia and has been used to infer brain shrinkage. However, whether ventricular enlargement is related to local overlying cortex and/or adjacent subcortical structures or whether it is related to brain volume change globally has not been assessed. We systematically assessed interrelations of ventricular volumes with gray and white matter volumes of 40 Brodmann areas (BAs), the thalamus and its medial dorsal nucleus and pulvinar, the internal capsule, caudate and putamen. We acquired structural MRI ( patients with schizophrenia (n=64) and healthy controls (n=56)) and diffusion tensor fractional anisotropy (FA) (untreated schizophrenia n=19, controls n=32). Volumes were assessed by manual tracing of central structures and a semi-automated parcellation of BAs. Patients with schizophrenia had increased ventricular size associated with decreased cortical gray matter volumes widely across the brain; a similar but less pronounced pattern was seen in normal controls; local correlations (e.g. temporal horn with temporal lobe volume) were not appreciably higher than non-local correlations (e.g. temporal horn with prefrontal volume). White matter regions adjacent to the ventricles similarly did not reveal strong regional relationships. FA and center of mass of the anterior limb of the internal capsule also appeared differentially influenced by ventricular volume but findings were similarly not regional. Taken together, these findings indicate that ventricular enlargement is globally interrelated with gray matter volume diminution but not directly correlated with volume loss in the immediately adjacent caudate, putamen, or internal capsule. The Author(s), 2011 Cerebral spinal fluid nationallicence Sulcal enlargement nationallicence Myelin nationallicence Fronto-thalamic connectivity nationallicence Horga Guillermo Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut Bernacer Javier Laboratory of Functional Neuromorphology, Clinica Universitaria, Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain aut Dusi Nicola Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico Giambattista Rossi, Piazzale L.A. Scuro 10, 37134, Verona, Italy aut Entis Jonathan Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut Chu Kingwai Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut Hazlett Erin Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Mehmet Haznedar M. Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Kemether Eileen Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut Byne William Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut Buchsbaum Monte Departments of Psychiatry and Radiology, NeuroPET Center, University of California, 11388 Sorrento Valley Road, Suite #100, 92121, San Diego, CA, USA aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 467-476 0940-1334 261:7<467 2011 261 406 https://doi.org/10.1007/s00406-011-0202-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0202-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Horga Guillermo Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Bernacer Javier Laboratory of Functional Neuromorphology, Clinica Universitaria, Universidad de Navarra, Avda. Pío XII 36, 31008, Pamplona, Spain aut NATIONALLICENCE 700 1- Dusi Nicola Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Policlinico Giambattista Rossi, Piazzale L.A. Scuro 10, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Entis Jonathan Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Chu Kingwai Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Hazlett Erin Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Mehmet Haznedar M. Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Kemether Eileen Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1230, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Byne William Department of Psychiatry, James J Peters VA Medical Center, 130 West Kingsbridge Road, 10468, Bronx, NY, USA aut NATIONALLICENCE 700 1- Buchsbaum Monte Departments of Psychiatry and Radiology, NeuroPET Center, University of California, 11388 Sorrento Valley Road, Suite #100, 92121, San Diego, CA, USA aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 467-476 0940-1334 261:7<467 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer