caa a22 4500 445343923 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00406-011-0196-4 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0196-4 An epidemiologic and clinical overview of medical and psychopathological comorbidities in major psychoses [Elektronische Daten] [A. Altamura, Marta Serati, Alessandra Albano, Riccardo Paoli, Ira Glick, Bernardo Dell'Osso] The presence of comorbidity in major psychoses (e.g., schizophrenia and psychotic subtypes of bipolar disorder and major depressive disorder) seems to be the rule rather than the exception in both DSM-IV and ICD-10. Examining comorbidity in major psychoses, however, requires an investigation into the different levels of comorbidity (either full-blown and subsyndromal) which should be analyzed in both psychopathological and medical fields. On one hand, the high prevalence of psychiatric comorbidity in major psychoses may be the result of the current nosographic systems. On the other hand, it may stem from a common neurobiological substrate. In fact, comorbid psychopathological conditions may share a biological vulnerability, given that dysfunction in specific brain areas may be responsible for different symptoms and syndromes. The high rates of comorbidity in major psychoses require targeted pharmacological treatments in order to effectively act on both the primary diagnosis and comorbid conditions. Nevertheless, few controlled trials in comorbid major psychoses had been carried out and treatment recommendations in this field have mostly an empirical basis. The aim of the present article is to provide a comprehensive and updated overview in relation to epidemiological and clinical issues of comorbidity in major psychoses. Springer-Verlag, 2011 Comorbidity nationallicence Major psychoses (MPs) nationallicence Schizophrenia (SK) nationallicence Bipolar disorder (BD) nationallicence Psychotic major depressive disorder (pMDD) nationallicence MPs : Major psychoses nationallicence SUD : Substance use disorder nationallicence SK : Schizophrenia nationallicence BD : Bipolar disorder nationallicence pMDD : Psychotic major depressive disorder nationallicence OCD : Obsessive compulsive disorder nationallicence PTSD : Post-traumatic stress disorder nationallicence SP : Social phobia nationallicence PD : Panic disorder nationallicence GAD : Generalized anxiety disorder nationallicence Altamura A. Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut Serati Marta Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut Albano Alessandra Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut Paoli Riccardo Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut Glick Ira Department of Psychiatry, Stanford University, Stanford University School of Medicine, Stanford, CA, USA aut Dell'Osso Bernardo Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 489-508 0940-1334 261:7<489 2011 261 406 https://doi.org/10.1007/s00406-011-0196-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0196-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altamura A. Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Serati Marta Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Albano Alessandra Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Paoli Riccardo Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut NATIONALLICENCE 700 1- Glick Ira Department of Psychiatry, Stanford University, Stanford University School of Medicine, Stanford, CA, USA aut NATIONALLICENCE 700 1- Dell'Osso Bernardo Department of Psychiatry, University of Milan, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/7(2011-10-01), 489-508 0940-1334 261:7<489 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer