caa a22 4500 445343931 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0150-x doi (NATIONALLICENCE)springer-10.1007/s00406-010-0150-x ADC changes in schizophrenia: a diffusion-weighted imaging study [Elektronische Daten] [Igor Nenadic, Gerd Wagner, Daniel Güllmar, Claudia Schachtzabel, Katrin von Consbruch, Sabine Köhler, Kathrin Koch, Martin Roebel, C. Schultz, Jürgen Reichenbach, Heinrich Sauer, Ralf Schlösser] Studies using diffusion tensor imaging (DTI) have shown multifocal reduction in anisotropy of white matter fibre tracts in schizophrenia, and a few of these also suggest changes in apparent diffusion coefficient (ADC). In this study, we assessed ADC in 18 patients with schizophrenia and 18 healthy controls using a voxel-based approach. We did not find evidence of statistically significant changes in ADC in either direction at P<0.05 (FDR corrected) using different smoothing filter sizes; only at an uncorrected threshold of P<0.001 did we find an increase in a small right prefrontal area close to our previous FA finding. Our findings therefore do not support ADC changes to be a marker of white matter or grey matter abnormalities in schizophrenia. Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder. Springer-Verlag, 2010 Schizophrenia nationallicence Brain nationallicence Magnetic resonance imaging (MRI) nationallicence Diffusion tensor imaging (DTI) nationallicence Apparent diffusion coefficient (ADC) nationallicence Nenadic Igor Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Wagner Gerd Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Güllmar Daniel Medical Physics Group, Institute for Diagnostic and Interventional Radiology (IDIR), Friedrich-Schiller-University of Jena, Philosophenweg 3, Jena, Germany aut Schachtzabel Claudia Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut von Consbruch Katrin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Köhler Sabine Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Koch Kathrin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Roebel Martin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Schultz C. Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Reichenbach Jürgen Medical Physics Group, Institute for Diagnostic and Interventional Radiology (IDIR), Friedrich-Schiller-University of Jena, Philosophenweg 3, Jena, Germany aut Sauer Heinrich Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut Schlösser Ralf Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 213-216 0940-1334 261:3<213 2011 261 406 https://doi.org/10.1007/s00406-010-0150-x text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0150-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nenadic Igor Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Wagner Gerd Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Güllmar Daniel Medical Physics Group, Institute for Diagnostic and Interventional Radiology (IDIR), Friedrich-Schiller-University of Jena, Philosophenweg 3, Jena, Germany aut NATIONALLICENCE 700 1- Schachtzabel Claudia Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- von Consbruch Katrin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Köhler Sabine Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Koch Kathrin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Roebel Martin Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Schultz C. Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Reichenbach Jürgen Medical Physics Group, Institute for Diagnostic and Interventional Radiology (IDIR), Friedrich-Schiller-University of Jena, Philosophenweg 3, Jena, Germany aut NATIONALLICENCE 700 1- Sauer Heinrich Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 700 1- Schlösser Ralf Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, 07743, Jena, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 213-216 0940-1334 261:3<213 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer