caa a22 4500 445343958 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0169-z doi (NATIONALLICENCE)springer-10.1007/s00406-010-0169-z Early-onset bipolar disorder: how about visual-spatial skills and executive functions? [Elektronische Daten] [Sara Lera-Miguel, Susana Andrés-Perpiñá, Rosa Calvo, Mar Fatjó-Vilas, Fañanás Lourdes, Luisa Lázaro] Early-onset bipolar disorder is an impairing condition that is strongly associated with genetic inheritance. Neurocognitive deficits are core traits of this disorder which seem to be present in both young and adult forms. Deficits in verbal memory and attention are persistent within euthymic phases in bipolar adults, adolescents, and children. In younger samples, including type I or II and not otherwise specified patients, executive functions are not widely impaired and the existence of visual-spatial deficits remains unclear. The main aim of this study was to compare the neurocognitive performance in young stabilized type I or II bipolar patients and healthy controls. Fifteen medicated adolescents with bipolar disorder and 15 healthy adolescents, matched in age and gender, were compared on visual-spatial skills (reasoning, memory, visual-motor accuracy) and executive functioning (attention and working memory, set-shifting, inhibition) using t-tests and MANCOVA. Correcting for verbal competence, MANCOVA showed that patients performed significantly worse than controls in letters and numbers sequencing (P=0.003), copy (P<0.001) and immediate recall (P=0.007) of the Rey Complex Figure Test, interference of the Stroop Color-Word Test (P=0.007) and non-perseverative errors on the Wisconsin Card Sorting Test (P=0.038). Impaired cognitive performance was found in young bipolar patients in working memory, visual-motor skills, and inhibitory control. Springer-Verlag, 2010 Early-onset bipolar disorder nationallicence Neuropsychology nationallicence Executive functions nationallicence Adolescent psychiatry nationallicence Child psychiatry nationallicence Lera-Miguel Sara Hospital Clínic of Barcelona, Barcelona, Spain aut Andrés-Perpiñá Susana Hospital Clínic of Barcelona, Barcelona, Spain aut Calvo Rosa Hospital Clínic of Barcelona, Barcelona, Spain aut Fatjó-Vilas Mar Universitat de Barcelona, Barcelona, Spain aut Lourdes Fañanás Universitat de Barcelona, Barcelona, Spain aut Lázaro Luisa Hospital Clínic of Barcelona, Barcelona, Spain aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 195-203 0940-1334 261:3<195 2011 261 406 https://doi.org/10.1007/s00406-010-0169-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0169-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lera-Miguel Sara Hospital Clínic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Andrés-Perpiñá Susana Hospital Clínic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Calvo Rosa Hospital Clínic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Fatjó-Vilas Mar Universitat de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Lourdes Fañanás Universitat de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Lázaro Luisa Hospital Clínic of Barcelona, Barcelona, Spain aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 195-203 0940-1334 261:3<195 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer