caa a22 4500 445343974 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0172-4 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0172-4 Adrenergic α2A receptor gene is not associated with methylphenidate response in adults with ADHD [Elektronische Daten] [Verônica Contini, Marcelo Victor, Caio Cerqueira, Evelise Polina, Eugênio Grevet, Carlos Salgado, Rafael Karam, Eduardo Vitola, Paulo Belmonte-de-Abreu, Claiton Bau] Adrenergic α2A receptor gene (ADRA2A) is one of the most promising candidate genes for ADHD pharmacogenetics. Thus far, three studies have investigated the association between the ADRA2A −1291 C>G polymorphism and the therapeutic response to methylphenidate (MPH) in children with ADHD, all of them with positive results. The aim of this study is to investigate, for the first time, the association between three ADRA2A polymorphisms (−1291 C>G, −262 G>A, and 1780 C>T) and the response to MPH in adults with ADHD. The sample comprises 165 Brazilians of European descent evaluated in the adult ADHD outpatient clinic of the Hospital de Clínicas de Porto Alegre. The diagnostic procedures followed the DSM-IV criteria. Drug response was assessed by both categorical and dimensional approaches, through the scales Swanson, Nolan, and Pelham Rating scale version IV and the Clinical Global Impression-Severity Scale, applied at the beginning and after the 30th day of treatment. We found no evidence of association between the three ADRA2A polymorphisms and the therapeutic response to MPH treatment. Our findings do not support a significant role for the ADRA2A gene in ADHD pharmacogenetics, at least among adult patients. Springer-Verlag, 2010 Attention deficit/hyperactivity disorder nationallicence Pharmacogenetics nationallicence ADRA2A gene nationallicence Methylphenidate nationallicence Contini Verônica Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut Victor Marcelo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Cerqueira Caio Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut Polina Evelise Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut Grevet Eugênio Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Salgado Carlos Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Karam Rafael Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Vitola Eduardo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Belmonte-de-Abreu Paulo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut Bau Claiton Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 205-211 0940-1334 261:3<205 2011 261 406 https://doi.org/10.1007/s00406-010-0172-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0172-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Contini Verônica Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Victor Marcelo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Cerqueira Caio Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Polina Evelise Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Grevet Eugênio Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Salgado Carlos Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Karam Rafael Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Vitola Eduardo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Belmonte-de-Abreu Paulo Adult ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Bau Claiton Departament of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul (UFRGS), Caixa Postal 15053, CEP 91501-970, Porto Alegre, RS, Brazil aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 205-211 0940-1334 261:3<205 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer