caa a22 4500 445343982 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0166-2 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0166-2 Proteome analyses of cultured astrocytes treated with MK-801 and clozapine: similarities with schizophrenia [Elektronische Daten] [Daniel Martins-de-Souza, Maria Lebar, Christoph Turck] On the basis of impaired glutamatergic transmission and the potential role of astrocytes in schizophrenia, we treated cultured astrocytes with MK-801, an NMDA-receptor antagonist, to investigate whether the resulting proteome changes are similar to those we found in our earlier proteome analysis of schizophrenia human brain tissue as well as to better comprehend the role of astrocytes in the disorder. Indeed, there are similarities. Furthermore, to verify the efficacy of clozapine and its effect over the proteome, we treated MK-801-treated astrocytes with clozapine. Interestingly, clozapine reversed protein changes induced by MK-801. The treatment of cell cultures with neural transmission agonists and antagonists might provide useful insights about psychiatric disorders. Springer-Verlag, 2010 Proteome nationallicence Proteomics nationallicence Astrocytes nationallicence Biomarkers nationallicence Mass spectrometry nationallicence Schizophrenia nationallicence Martins-de-Souza Daniel Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut Lebar Maria Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut Turck Christoph Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 217-228 0940-1334 261:3<217 2011 261 406 https://doi.org/10.1007/s00406-010-0166-2 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0166-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martins-de-Souza Daniel Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut NATIONALLICENCE 700 1- Lebar Maria Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut NATIONALLICENCE 700 1- Turck Christoph Max Planck Institute of Psychiatry, Kraepelinstr. 2, 80804, Munich, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 217-228 0940-1334 261:3<217 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer