caa a22 4500 445343990 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0164-4 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0164-4 The effect of a 4-week treatment with reboxetine on metabolic parameters of depressed inpatients [Elektronische Daten] [Georgios Paslakis, Maria Gilles, Florian Lederbogen, Claudia Schilling, Barbara Scharnholz, Michael Deuschle] In the present study, we examined several metabolic parameters in a group of 19 acutely depressed inpatients with major depression (DSM-IV) at baseline and investigated their development after 4weeks of antidepressant treatment with reboxetine (8-12mg per day). We performed oral glucose tolerance tests and additionally assessed free saliva cortisol and post-dexamethasone cortisol levels, as well as whole cholesterol, HDL- and LDL-cholesterol, triglycerides, free fatty acids, waist and hip circumference, heart rate, systolic and diastolic blood pressure. Furthermore, we evaluated the incidence of a metabolic syndrome and investigated the metabolic changes in depressed patients with and without a metabolic syndrome. We found 42.1% of patients to fulfil the criteria for a metabolic syndrome. Overall, reboxetine was well tolerated with essentially no side effects during the observation period. A 4-week treatment with reboxetine showed a beneficial effect on several metabolic parameters that was independent from treatment outcome and could therefore theoretically be attributed to the pharmacological profile of the drug. Due to the preliminary character of the present investigation, no conclusions about the clinical efficacy of reboxetine can be drawn. Springer-Verlag, 2010 Depression nationallicence Metabolic syndrome nationallicence Antidepressant nationallicence Reboxetine nationallicence HPA axis nationallicence Cortisol nationallicence Paslakis Georgios Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut Gilles Maria Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut Lederbogen Florian Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut Schilling Claudia Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut Scharnholz Barbara Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut Deuschle Michael Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 173-177 0940-1334 261:3<173 2011 261 406 https://doi.org/10.1007/s00406-010-0164-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0164-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paslakis Georgios Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Gilles Maria Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Lederbogen Florian Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Schilling Claudia Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Scharnholz Barbara Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 700 1- Deuschle Michael Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, J5, 68159, Mannheim, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 173-177 0940-1334 261:3<173 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer