caa a22 4500 445344024 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00406-010-0165-3 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0165-3 A systematic experimental neuropsychological investigation of the functional integrity of working memory circuits in major depression [Elektronische Daten] [Oliver Gruber, David Zilles, Jennifer Kennel, Eva Gruber, Peter Falkai] Verbal and visuospatial working memory (WM) impairment is a well-documented finding in psychiatric patients suffering from major psychoses such as schizophrenia or bipolar affective disorder. However, in major depression (MDD) the literature on the presence and the extent of WM deficits is inconsistent. The use of a multitude of different WM tasks most of which lack process-specificity may have contributed to these inconsistencies. Eighteen MDD patients and 18 healthy controls matched with regard to age, gender and education were tested using process- and circuit-specific WM tasks for which clear brain-behaviour relationships had been established in prior functional neuroimaging studies. Patients suffering from acute MDD showed a selective impairment in articulatory rehearsal of verbal information in working memory. By contrast, visuospatial WM was unimpaired in this sample. There were no significant correlations between symptom severity and WM performance. These data indicate a dysfunction of a specific verbal WM system in acutely ill patients with MDD. As the observed functional deficit did not correlate with different symptom scores, further, longitudinal studies are required to clarify whether and how this deficit is related to illness acuity and clinical state of MDD patients. The Author(s), 2010 Major depression nationallicence Neurocognition nationallicence Cognitive endophenotype nationallicence Psychosis nationallicence Brain imaging nationallicence Gruber Oliver Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut Zilles David Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut Kennel Jennifer Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany aut Gruber Eva Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany aut Falkai Peter Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 179-184 0940-1334 261:3<179 2011 261 406 https://doi.org/10.1007/s00406-010-0165-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0165-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gruber Oliver Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut NATIONALLICENCE 700 1- Zilles David Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut NATIONALLICENCE 700 1- Kennel Jennifer Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany aut NATIONALLICENCE 700 1- Gruber Eva Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany aut NATIONALLICENCE 700 1- Falkai Peter Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry, University Medical Centre, Georg August University, Goettingen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/3(2011-04-01), 179-184 0940-1334 261:3<179 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer