caa a22 4500 445344113 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00406-011-0249-8 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0249-8 Progressive pathology is functionally linked to the domains of language and emotion: meta-analysis of brain structure changes in schizophrenia patients [Elektronische Daten] [Thomas Nickl-Jockschat, Frank Schneider, Alena Pagel, Angie Laird, Peter Fox, Simon Eickhoff] Schizophrenia is a neuropsychiatric disorder entailing progressive psychotic, cognitive and affective symptoms. Several imaging studies identified brain structure abnormalities in schizophrenia patients, particularly in fronto-temporal regions and evidence for progressive anatomical changes. Here, we synthesised these findings by quantitative coordinate-based meta-analysis, assessing regions of consistently reported brain structure changes, their physiological functions and the correlation of their likelihood with disease duration. The meta-analysis revealed four significant clusters of convergent grey matter reduction, while one cluster indicated higher grey matter values in patients. A voxel-wise analysis revealed a correlation between grey matter reduction and disease duration in the left anterior insula. Functional characterisation revealed significant association with reward, affective processing and language functions. The current analysis allowed the identification of consistent morphometric changes across a large sample of studies in regions that are associated with neurophysiological functions that are altered as hallmarks of schizophrenia psychopathology. The observation that the location of presumably progressive pathology is functionally linked to language and emotion is well in line with increasing deficits in these domains with disease progression in schizophrenia. Springer-Verlag, 2011 Schizophrenia nationallicence Brain structure nationallicence Anatomical likelihood estimation nationallicence Disease duration nationallicence Structure-function relationship nationallicence BrainMap nationallicence Nickl-Jockschat Thomas Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut Pagel Alena Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut Laird Angie Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA aut Fox Peter Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA aut Eickhoff Simon Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 166-171 0940-1334 261<166 2011 261 406 https://doi.org/10.1007/s00406-011-0249-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0249-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nickl-Jockschat Thomas Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut NATIONALLICENCE 700 1- Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut NATIONALLICENCE 700 1- Pagel Alena Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut NATIONALLICENCE 700 1- Laird Angie Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Fox Peter Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Eickhoff Simon Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstrasse 30, D-52074, Aachen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 166-171 0940-1334 261<166 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer