caa a22 4500 445344121 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00406-011-0264-9 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0264-9 Neural correlates of the attention network test in schizophrenia [Elektronische Daten] [Volker Backes, Thilo Kellermann, Bianca Voss, Jörn Krämer, Conny Depner, Frank Schneider, Ute Habel] Attentional deficits are prominent in schizophrenia, affecting nearly all cognitive functions. Human attention comprises three essential components: alerting, orienting and executive control. For the assessment of these functions, the attention network test (ANT) has been proposed and used in healthy controls and patients. In schizophrenia, the ANT has revealed behavioral deficits; however, the corresponding neural correlates have not been examined. In the present study, neural correlates of attention were investigated in 17 schizophrenia patients and 17 healthy controls using the ANT with fMRI. Behavioral deficits emerged in the alertness system with a reduced efficiency for temporal cues. In fMRI, changes were observed for all three domains-alerting, orienting and conflict-and revealed hyper- as well as hypoactivation in patients. Affected regions during alerting comprised a broad fronto-temporo-parieto-occipito-cerebellar network, while differences during orienting mainly tapped fronto-parietal regions and during conflict processing a thalamo-frontal-temporal occipital network including the postcentral regions. In general, hyperactivations were positively correlated with more severe psychopathologial symptoms. Springer-Verlag, 2011 ANT nationallicence fMRI nationallicence Alertness nationallicence Orienting nationallicence Backes Volker Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Kellermann Thilo Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Voss Bianca Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Krämer Jörn Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Depner Conny Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut Habel Ute Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 155-160 0940-1334 261<155 2011 261 406 https://doi.org/10.1007/s00406-011-0264-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0264-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Backes Volker Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Kellermann Thilo Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Voss Bianca Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Krämer Jörn Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Depner Conny Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Schneider Frank Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 700 1- Habel Ute Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 155-160 0940-1334 261<155 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer