caa a22 4500 445344180 CHVBK 20180317142823.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00406-011-0242-2 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0242-2 Schizophrenia as a disorder of disconnectivity [Elektronische Daten] [Andrea Schmitt, Alkomiet Hasan, Oliver Gruber, Peter Falkai] Schizophrenia is considered as a neurodevelopmental disorder with genetic and environmental factors playing a role. Animal models show that developmental hippocampal lesions are causing disconnectivity of the prefrontal cortex. Magnetic resonance imaging and postmortem investigations revealed deficits in the temporoprefrontal neuronal circuit. Decreased oligodendrocyte numbers and expression of oligodendrocyte genes and synaptic proteins may contribute to disturbances of micro- and macro-circuitry in the pathophysiology of the disease. Functional connectivity between cortical areas can be investigated with high temporal resolution using transcranial magnetic stimulation (TMS), electroencephalography (EEG), and magnetoencephalography (MEG). In this review, disconnectivity between different cortical areas in schizophrenia patients is described. The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed. The Author(s), 2011 Schizophrenia nationallicence Connectivity nationallicence Magnetic resonance imaging nationallicence Transcranial magnetic stimulation nationallicence Magnetencephalography nationallicence Schmitt Andrea Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Hasan Alkomiet Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Gruber Oliver Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut Falkai Peter Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 150-154 0940-1334 261<150 2011 261 406 https://doi.org/10.1007/s00406-011-0242-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0242-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmitt Andrea Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Hasan Alkomiet Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Gruber Oliver Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 700 1- Falkai Peter Department of Psychiatry and Psychotherapy, University of Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261(2011-11-01), 150-154 0940-1334 261<150 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer