caa a22 4500 445344288 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0148-4 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0148-4 Dysfunctional pain modulation in somatoform pain disorder patients [Elektronische Daten] [Klug Stefanie, Anderer Peter, Saletu-Zyhlarz Gerda, Freidl Marion, Saletu Bernd, Prause Wolfgang, Aigner Martin] To date, pain perception is thought to be a creative process of modulation carried out by an interplay of pro- and anti-nociceptive mechanisms. Recent research demonstrates that pain experience constitutes the result of top-down processes represented in cortical descending pain modulation. Cortical, mainly medial and frontal areas, as well as subcortical structures such as the brain stem, medulla and thalamus seem to be key players in pain modulation. An imbalance of pro- and anti-nociceptive mechanisms are assumed to cause chronic pain disorders, which are associated with spontaneous pain perception without physiologic scaffolding or exaggerated cortical activation in response to pain exposure. In contrast to recent investigations, the aim of the present study was to elucidate cortical activation of somatoform pain disorder patients during baseline condition. Scalp EEG, quantitative Fourier-spectral analyses and LORETA were employed to compare patient group (N=15) to age- and sex-matched controls (N=15) at rest. SI, SII, ACC, SMA, PFC, PPC, insular, amygdale and hippocampus displayed significant spectral power reductions within the beta band range (12-30Hz). These results suggest decreased cortical baseline arousal in somatoform pain disorder patients. We finally conclude that obtained results may point to an altered baseline activity, maybe characteristic for chronic somatoform pain disorder. Springer-Verlag, 2010 EEG nationallicence Beta-3 band nationallicence Pain modulation nationallicence Pain matrix nationallicence SI nationallicence EEG : Electroencephalogram nationallicence BA : Brodman area nationallicence rCBF : Regional cerebral blood flow nationallicence SMA : Supplementary motor area nationallicence PPC : Posterior parietal cortex nationallicence PFC : Prefrontal cortex nationallicence SI : Primary somatosensory cortex nationallicence SII : Secondary somatosensory cortex nationallicence ACC : Anterior cingulate cortex nationallicence rACC : Rostral anterior cingulate cortex nationallicence PAG : Periaqueductal grey nationallicence AI : Anterior insula nationallicence CBP : Chronic back pain patients nationallicence IBS : Irritable bowel syndrome nationallicence GI : Gastrointestinal nationallicence EOG : Electrooculogram nationallicence ICA : Independent component analysis nationallicence Stefanie Klug Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Peter Anderer Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Gerda Saletu-Zyhlarz Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Marion Freidl Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Bernd Saletu Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Wolfgang Prause Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut Martin Aigner Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 267-275 0940-1334 261:4<267 2011 261 406 https://doi.org/10.1007/s00406-010-0148-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0148-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stefanie Klug Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Peter Anderer Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Gerda Saletu-Zyhlarz Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Marion Freidl Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Bernd Saletu Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Wolfgang Prause Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Martin Aigner Department of Psychiatry and Psychotherapy, General Hospital of Vienna, Medical University of Vienna, Währinger-Gürtel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 267-275 0940-1334 261:4<267 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer