caa a22 4500 445344318 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0147-5 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0147-5 Localized gray matter volume abnormalities in generalized anxiety disorder [Elektronische Daten] [Anne Schienle, Franz Ebner, Axel Schäfer] Generalized anxiety disorder (GAD) is characterized by excessive and persistent worrying. Neural substrates of this disorder are insufficiently understood, which relates to functional as well as to structural brain abnormalities. Especially, findings on the neuroanatomy of GAD have been inconsistent and were predominantly derived from pediatric samples. Therefore, we studied adult patients. Thirty-one women (16 patients with GAD and 15 healthy control participants) underwent structural MRI scanning. Gray matter volumes for specific brain regions involved in worrying, anticipatory anxiety, and emotion regulation were analyzed by means of voxel-based morphometry. Relative to controls, patients with GAD had larger volumes of the amygdala and the dorsomedial prefrontal cortex (DMPFC). Moreover, patients' self-reports on symptom severity were positively correlated with volumes of the DMPFC and the anterior cingulate cortex. Patients with GAD show localized gray matter volume differences in brain regions associated with anticipatory anxiety and emotion regulation. This abnormality may represent either a predisposition for GAD or a consequence of disorder-specific behavior, such as chronic worrying. This issue should be addressed in future MRI studies. Springer-Verlag, 2010 Amygdala nationallicence Dorsomedial prefrontal cortex nationallicence Voxel-based morphometry nationallicence Generalized anxiety disorder nationallicence Schienle Anne Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, 8010, Graz, Austria aut Ebner Franz Department of Radiology, Medical University of Graz, Graz, Austria aut Schäfer Axel Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, 8010, Graz, Austria aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 303-307 0940-1334 261:4<303 2011 261 406 https://doi.org/10.1007/s00406-010-0147-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0147-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schienle Anne Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, 8010, Graz, Austria aut NATIONALLICENCE 700 1- Ebner Franz Department of Radiology, Medical University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Schäfer Axel Department of Clinical Psychology, University of Graz, Universitätsplatz 2/III, 8010, Graz, Austria aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 303-307 0940-1334 261:4<303 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer