caa a22 4500 445344342 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0134-x doi (NATIONALLICENCE)springer-10.1007/s00406-010-0134-x Psychological distress and C-reactive protein: do health behaviours and pathophysiological factors modify the association? [Elektronische Daten] [Pekka Puustinen, Hannu Koponen, Hannu Kautiainen, Pekka Mäntyselkä, Mauno Vanhala] The objective of this study is to examine the association of psychological distress to high-sensitivity C-reactive protein (hsCRP) levels and to examine the potential mediating role of health behaviours and pathophysiological factors. A total of 883 (393 men and 490 women) subjects, aged 36-56years, participated in a population-based, cross-sectional study from 1997 to 1998 in Pieksämäki, Finland. Various clinical, biochemical and behavioural factors were measured, including hsCRP concentration. Psychological distress was measured using the 12-item General Health Questionnaire (GHQ-12). Subjects with low psychological distress (0 points in GHQ-12) were younger and more physically active, and their mean hsCRP level was lower when compared to subjects with medium (1-3 points) or high (4-12 points) psychological distress (1.26±1.36, 1.53±1.75 and 1.70±1.68mg/l, respectively, P for linearity=0.003). Psychological distress was also associated with high relative cardiovascular risk (hsCRP >3.00mg/l). After adjusting for gender, age, BMI, smoking, use of alcohol and leisure time physical activity, odds ratios for hsCRP >3.00mg/l in the groups that had medium and high psychological distress were 1.32 (95% CI: 0.81-2.16) and 1.79 (95% CI: 1.05-3.04), respectively, compared with the low distress group (P for linearity 0.032). Psychological distress was associated with elevated hsCRP levels representing high relative cardiovascular risk. This association remained after adjusting for health behaviours and pathophysiological factors, supporting a direct, physiological link between psychological distress and inflammation. CRP could be an important pathophysiological mechanism through which psychological factors are associated with cardiovascular disease. Springer-Verlag, 2010 Psychological distress nationallicence GHQ nationallicence C-reactive protein nationallicence Health behaviour nationallicence Puustinen Pekka Centre for Social and Health Services, PL 227, 70101, Kuopio, Finland aut Koponen Hannu Department of Psychiatry, University of Eastern Finland, Kuopio, Finland aut Kautiainen Hannu Unit of Family Practice, Central Hospital of Middle Finland, Jyväskylä, Finland aut Mäntyselkä Pekka School of Medicine, Unit of Primary Health Care, University of Eastern Finland, Kuopio, Finland aut Vanhala Mauno School of Medicine, Unit of Primary Health Care, University of Eastern Finland, Kuopio, Finland aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 277-284 0940-1334 261:4<277 2011 261 406 https://doi.org/10.1007/s00406-010-0134-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0134-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Puustinen Pekka Centre for Social and Health Services, PL 227, 70101, Kuopio, Finland aut NATIONALLICENCE 700 1- Koponen Hannu Department of Psychiatry, University of Eastern Finland, Kuopio, Finland aut NATIONALLICENCE 700 1- Kautiainen Hannu Unit of Family Practice, Central Hospital of Middle Finland, Jyväskylä, Finland aut NATIONALLICENCE 700 1- Mäntyselkä Pekka School of Medicine, Unit of Primary Health Care, University of Eastern Finland, Kuopio, Finland aut NATIONALLICENCE 700 1- Vanhala Mauno School of Medicine, Unit of Primary Health Care, University of Eastern Finland, Kuopio, Finland aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 277-284 0940-1334 261:4<277 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer