caa a22 4500 445344350 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0140-z doi (NATIONALLICENCE)springer-10.1007/s00406-010-0140-z Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD [Elektronische Daten] [Susanne Steinlechner, Norbert Brüggemann, Vera Sobottka, Alexander Benthien, Birte Behn, Christine Klein, Gabriele Schmid, Rebekka Lencer] Attention-deficit hyperactivity disorder (ADHD) is a common disorder with estimated prevalence of 5% in children and 3.4% in adults. Psychiatric disorders are a frequent concomitant feature. Restless legs syndrome (RLS) may mimic the symptoms of ADHD. The aim of the study is to evaluate whether the presence of RLS predicts occurrence of psychiatric disorders in parents of children with ADHD. Thirty-seven parents of 26 children with ADHD were examined for RLS and for lifetime prevalence rates of psychiatric disorders and personality disorders based on the Structured Clinical Interview for DSM-IV Diagnoses (SCID). Prevalence rates in parents were 29.7% for RLS, 67.6% for Axis I and 40.5% for Axis II disorders. Mothers revealed higher rates for depression, anxiety disorders and ADHD than fathers, whereas personality disorders occurred at higher rates in fathers. The presence of RLS predicted a diagnosis of ADHD (odds ratio (OR) 21.9), agoraphobia (OR=20.4) and any anxiety disorder (OR=8.5). Although limited by the small sample size, we found evidence for increased rates of cluster B personality disorders (OR=59.3) in parents with RLS. All parents of the latter group (100%) reported a positive family history of psychiatric disorders which was not the case in parents without RLS (69.2%) excluding the index children with ADHD. RLS seems to indicate increased vulnerability for psychiatric disorders, i.e., ADHD and anxiety disorders, in a subgroup of parents from ADHD children. Synaptic dysfunction affecting dopaminergic transmission among other transmitter systems may be a common final pathway related to the phenotypic spectrum of ADHD. Springer-Verlag, 2010 Restless legs syndrome nationallicence ADHD nationallicence Psychiatric disorders nationallicence Personality disorders nationallicence Family history nationallicence Phenotypic spectrum nationallicence Steinlechner Susanne Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Brüggemann Norbert Department of Neurology, University of Luebeck, Luebeck, Germany aut Sobottka Vera Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Benthien Alexander Department of Pediatrics, University of Luebeck, Luebeck, Germany aut Behn Birte Department of Pediatrics, University of Luebeck, Luebeck, Germany aut Klein Christine Department of Neurology, University of Luebeck, Luebeck, Germany aut Schmid Gabriele Department of Pediatrics, University of Luebeck, Luebeck, Germany aut Lencer Rebekka Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 285-291 0940-1334 261:4<285 2011 261 406 https://doi.org/10.1007/s00406-010-0140-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0140-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steinlechner Susanne Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Brüggemann Norbert Department of Neurology, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Sobottka Vera Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Benthien Alexander Department of Pediatrics, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Behn Birte Department of Pediatrics, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Klein Christine Department of Neurology, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Schmid Gabriele Department of Pediatrics, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Lencer Rebekka Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 285-291 0940-1334 261:4<285 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer