caa a22 4500 445344377 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0146-6 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0146-6 Cognitive performance and smoking in first-episode psychosis: the self-medication hypothesis [Elektronische Daten] [Rafael Segarra, Arantzazu Zabala, Jose Eguíluz, Natalia Ojeda, Edorta Elizagarate, Pedro Sánchez, Javier Ballesteros, Miguel Gutiérrez] The self-medication hypothesis attempts to explain the extraordinary high levels of cigarette smoking in schizophrenia; patients may smoke in an attempt to reduce their cognitive deficits, symptoms, or the side effects of antipsychotics. In a previous report, we detected beneficial performance in attention and working memory in patients with first-episode psychosis who smoked compared to non-smoking patients soon after stabilization. In the present study, we examine differences in the course of those deficits 12months after the initiation of antipsychotic treatment. We also explore the association between smoking and symptoms and side effects of medication. Neuropsychological assessments were performed at baseline, month 6 and month 12 using a computerized battery that included measures of sustained attention (Continuous Performance Test CPT-O), selective attention (Stroop interference task) and working memory (CPT-XO). Patients met the criterion of fitting in the same smoking category throughout the study: non-smoker (n=15; 0cigarettes/day) and smoker (n=26; >15cigarettes/day). The non-smoking patients showed significant cognitive improvements, whereas smoking patients lost their superior baseline performance, which was probably obtained through nicotinic stimulation, at the 6- and 12-month assessments due to a static course of deficits. Smokers did not obtain any cognitive benefit after instauration of treatment and worsen their symptoms over the first year. These results suggest that smoking may constitute a marker of a more severe illness. Smoking was not associated with fewer extrapyramidal side effects. Smoking might improve attention and working memory to a similarly modest extent as atypical antipsychotics and could reflect an effort to ameliorate these cognitive dysfunctions previous to treatment instauration. Springer-Verlag, 2010 First-episode psychosis nationallicence Cognitive deficits nationallicence Cigarette smoking nationallicence Nicotine nationallicence Self-medication nationallicence Segarra Rafael Department of Psychiatry, Cruces Hospital, Osakidetza - Basque Health System, Vizcaya, Spain aut Zabala Arantzazu Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut Eguíluz Jose Department of Psychiatry, Cruces Hospital, Osakidetza - Basque Health System, Vizcaya, Spain aut Ojeda Natalia Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of the Basque Country UPV/EHU, Spain aut Elizagarate Edorta Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut Sánchez Pedro Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut Ballesteros Javier Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut Gutiérrez Miguel Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 241-250 0940-1334 261:4<241 2011 261 406 https://doi.org/10.1007/s00406-010-0146-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0146-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Segarra Rafael Department of Psychiatry, Cruces Hospital, Osakidetza - Basque Health System, Vizcaya, Spain aut NATIONALLICENCE 700 1- Zabala Arantzazu Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut NATIONALLICENCE 700 1- Eguíluz Jose Department of Psychiatry, Cruces Hospital, Osakidetza - Basque Health System, Vizcaya, Spain aut NATIONALLICENCE 700 1- Ojeda Natalia Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, University of the Basque Country UPV/EHU, Spain aut NATIONALLICENCE 700 1- Elizagarate Edorta Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut NATIONALLICENCE 700 1- Sánchez Pedro Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut NATIONALLICENCE 700 1- Ballesteros Javier Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut NATIONALLICENCE 700 1- Gutiérrez Miguel Department of Neuroscience, Psychiatry Section, School of Medicine and Odontology, Universidad del País Vasco UPV/EHU, Barrio Sarriena s/n, 48940, Lejona, Vizcaya, Spain aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 241-250 0940-1334 261:4<241 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer