caa a22 4500 445344385 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00406-010-0137-7 doi (NATIONALLICENCE)springer-10.1007/s00406-010-0137-7 Transcranial magnetic stimulation for the treatment of depression: feasibility and results under naturalistic conditions: a retrospective analysis [Elektronische Daten] [Elmar Frank, Peter Eichhammer, Julia Burger, Marc Zowe, Michael Landgrebe, Göran Hajak, Berthold Langguth] An increasing number of controlled studies strongly support an antidepressant effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex. However, these data come from highly selected study populations. Whether rTMS is a feasible therapeutic tool for the treatment of depression under naturalistic condition has not yet been addressed. Here, we report results from 232 depressive patients [aged 20-76years, baseline Hamilton Depression Rating Score (HDRS-21) 24.0±7.3] treated with rTMS add-on to continued psychopharmacological treatment in a naturalistic clinical setting. Two thousand stimuli of 20-Hz rTMS were applied daily over the left dorsolateral prefrontal cortex with an intensity of 110% of motor threshold. Treatment duration was individually planned and varied between 10 and 20 sessions. In average, patients received 13±6.1 rTMS sessions. In 90% of the cases, treatment was terminated regularly. No severe side effects were observed. Only four patients stopped rTMS treatment because of side effects. Ratings with the HDRS-21 before and after treatment were available in 130 patients. The average improvement of the HDRS-21 in this subsample was 9.0±9.2 points. Fifty-three patients had an improvement of 50% or more. These results document that rTMS is feasible, safe and well tolerated under naturalistic conditions. Springer-Verlag, 2010 Transcranial magnetic stimulation nationallicence Depression nationallicence Treatment nationallicence Naturalistic condition nationallicence Medication-resistant depression nationallicence Frank Elmar Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Eichhammer Peter Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Burger Julia Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Zowe Marc Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Landgrebe Michael Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Hajak Göran Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut Langguth Berthold Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 261-266 0940-1334 261:4<261 2011 261 406 https://doi.org/10.1007/s00406-010-0137-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-010-0137-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frank Elmar Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Eichhammer Peter Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Burger Julia Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Zowe Marc Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Landgrebe Michael Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Hajak Göran Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 700 1- Langguth Berthold Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/4(2011-06-01), 261-266 0940-1334 261:4<261 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer