caa a22 4500 445344415 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0207-5 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0207-5 Neuropsychological endophenotypes in attention-deficit/hyperactivity disorder: a review of genetic association studies [Elektronische Daten] [Oussama Kebir, Ridha Joober] As a relatively large body of research has been published up to now, it may be informative to explore whether the use of endophenotypes has produced consistent findings in attention-deficit hyperactivity disorder (ADHD). We reviewed the results of genetic studies investigating associations between putative susceptibility genes for ADHD and neuropsychological traits relevant for this disorder. A PubMed database search identified 47 studies. Most of them (n=36) examined a single candidate gene, while seven studies examined two or three genes and only four studies examined 10 genes or more. The most investigated genes were DRD4, DAT1, COMT, MAOA, and DBH. Regarding DRD4, association of high reaction time variability with the 7-R allele absence appears to be the most consistent result. Speed of processing, set shifting, and cognitive impulsiveness were less frequently investigated, but seem to be altered in the 7-R allele carriers. Regarding DAT1, majority of studies reported negative results indicating that this gene may have a modulating effect rather than direct influence on cognitive functioning. The other genes were investigated in fewer studies, and the reported findings need to be replicated. The principal methodological issues that could represent confounding factors and may explain conflicting results are discussed. Springer-Verlag, 2011 ADHD nationallicence Association study nationallicence Cognitive nationallicence Genetics nationallicence Neuropsychological endophenotype nationallicence Kebir Oussama INSERM, U894, University Paris Descartes, Paris, France aut Joober Ridha Department of Psychiatry, McGill University, Montreal, QC, Canada aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 583-594 0940-1334 261:8<583 2011 261 406 https://doi.org/10.1007/s00406-011-0207-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0207-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kebir Oussama INSERM, U894, University Paris Descartes, Paris, France aut NATIONALLICENCE 700 1- Joober Ridha Department of Psychiatry, McGill University, Montreal, QC, Canada aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 583-594 0940-1334 261:8<583 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer