caa a22 4500 445344431 CHVBK 20180317142824.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00406-011-0194-6 doi (NATIONALLICENCE)springer-10.1007/s00406-011-0194-6 Major depression, borderline personality disorder, and visceral fat content in women [Elektronische Daten] [Wiebke Greggersen, Sebastian Rudolf, Eva Fassbinder, Leif Dibbelt, Beate Stoeckelhuber, Fritz Hohagen, Kerstin Oltmanns, Kai Kahl, Ulrich Schweiger] Major depressive disorder (MDD) is associated with increased volumes of visceral fat and a high prevalence of the metabolic syndrome. In turn, affective disorders are frequently found in patients with borderline personality disorder (BPD). It is therefore unclear whether BPD per se may influence body composition. In order to clarify a potential relationship between BPD and body composition, we measured visceral fat content (VFC) in young depressed women with and without comorbid BPD and related this parameter to various features of the metabolic syndrome. Visceral fat content was measured by magnetic resonance imaging in 22 premenopausal women with MDD only, in 44 women with comorbid MDD and BPD, in 12 female BPD patients without MDD, and in 34 healthy women (CG). Data showed that depressed women without comorbid BPD had a 335% higher VFC and women with comorbid BPD had a 250% higher VFC than the CG women. When controlling for age, data showed significant effects of MDD on VFC (F=8.4; P=0.005). However, BPD, with or without MDD, was not related to VFC. Young depressed women with and without comorbid BPD display increased visceral fat content when compared to control subjects and may therefore constitute a risk group for the development of the metabolic syndrome. BPD per se is not an additive risk factor in this context. Springer-Verlag, 2011 Visceral fat content nationallicence Body composition nationallicence Major depressive disorder nationallicence Borderline personality disorder nationallicence Metabolic syndrome nationallicence Cytokines nationallicence Greggersen Wiebke Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut Rudolf Sebastian Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut Fassbinder Eva Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut Dibbelt Leif Department of Clinical Chemistry, University of Luebeck, Luebeck, Germany aut Stoeckelhuber Beate Department of Radiology, University of Luebeck, Luebeck, Germany aut Hohagen Fritz Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut Oltmanns Kerstin Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut Kahl Kai Department for Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany aut Schweiger Ulrich Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 551-557 0940-1334 261:8<551 2011 261 406 https://doi.org/10.1007/s00406-011-0194-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00406-011-0194-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greggersen Wiebke Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Rudolf Sebastian Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Fassbinder Eva Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Dibbelt Leif Department of Clinical Chemistry, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Stoeckelhuber Beate Department of Radiology, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Hohagen Fritz Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Oltmanns Kerstin Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 700 1- Kahl Kai Department for Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Schweiger Ulrich Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany aut NATIONALLICENCE 773 0- European Archives of Psychiatry and Clinical Neuroscience Springer-Verlag 261/8(2011-12-01), 551-557 0940-1334 261:8<551 2011 261 406 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer